Advanced Porous Materials Unit, IMDEA Energy, Ramón de la Sagra 3, 28935 Móstoles-Madrid, Spain.
Wallenberg Initiative Materials Science for Sustainability, Department of Materials and Environmental Chemistry, Stockholm University, Stockholm 106 91, Sweden.
ACS Appl Mater Interfaces. 2024 Jun 26;16(25):32118-32127. doi: 10.1021/acsami.4c06174. Epub 2024 Jun 11.
The SARS-CoV-2 (COVID-19) pandemic outbreak led to enormous social and economic repercussions worldwide, felt even to this date, making the design of new therapies to combat fast-spreading viruses an imperative task. In the face of this, diverse cutting-edge nanotechnologies have risen as promising tools to treat infectious diseases such as COVID-19, as well as challenging illnesses such as cancer and diabetes. Aside from these applications, nanoscale metal-organic frameworks (nanoMOFs) have attracted much attention as novel efficient drug delivery systems for diverse pathologies. However, their potential as anti-COVID-19 therapeutic agents has not been investigated. Herein, we propose a pioneering anti-COVID MOF approach by studying their potential as safe and intrinsically antiviral agents through screening various nanoMOF. The iron(III)-trimesate MIL-100 showed a noteworthy antiviral effect against SARS-CoV-2 at the micromolar range, ensuring a high biocompatibility profile (90% of viability) in a real infected human cellular scenario. This research effectively paves the way toward novel antiviral therapies based on nanoMOFs, not only against SARS-CoV-2 but also against other challenging infectious and/or pulmonary diseases.
SARS-CoV-2（COVID-19）大流行在全球范围内造成了巨大的社会和经济影响，甚至到今天仍能感受到，因此设计新的疗法来对抗快速传播的病毒是当务之急。面对这种情况，各种前沿的纳米技术已经成为治疗 COVID-19 等传染病以及癌症和糖尿病等挑战性疾病的有前途的工具。除了这些应用之外，纳米级金属有机骨架（nanoMOF）作为治疗各种疾病的新型高效药物输送系统也引起了广泛关注。然而，它们作为抗 COVID-19 治疗剂的潜力尚未得到研究。在这里，我们通过筛选各种 nanoMOF 来研究它们作为安全和固有抗病毒药物的潜力，提出了一种开创性的抗 COVID MOF 方法。三价铁-均苯三甲酸 MIL-100 在微摩尔范围内对 SARS-CoV-2 表现出显著的抗病毒作用，在真实感染的人类细胞环境中确保了高生物相容性（90%的存活率）。这项研究为基于 nanoMOF 的新型抗病毒疗法铺平了道路，不仅针对 SARS-CoV-2，还针对其他具有挑战性的传染病和/或肺部疾病。
