Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Department of Neurology, The Deqing People's Hospital, Huzhou, Zhejiang, China.
Brain Behav. 2020 Apr;10(4):e01530. doi: 10.1002/brb3.1530. Epub 2020 Feb 17.
The association between prediabetes and functional outcome in cerebrovascular diseases is controversial. No study has explored the relationship between prediabetes and functional outcome in intracerebral hemorrhage patients. Our study aimed to explore the association between prediabetes and functional outcome in intracerebral hemorrhage patients 1 month poststroke.
One hundred and fifty intracerebral hemorrhage patients were consecutively recruited within the first 24 hr after admission and were followed up for 1 month. Patients were divided into a diabetes mellitus group, a prediabetes group, and a nondiabetic group by fasting glucose levels, 2-hr postprandial blood glucose levels, and glycosylated hemoglobin levels. Patients with modified Rankin Scale scores >2 at 1 month were defined as having a poor functional outcome.
The prediabetes group had a higher risk of poor functional outcome than the nondiabetic group in intracerebral hemorrhage patients (37.9% vs. 9.8%, χ = 11.521, p = .001). According to the logistic regression analyses, prediabetes was associated with a poor functional outcome in intracerebral hemorrhage patients after adjusting for confounding factors (odds ratio = 6.167, 95% confidence interval = 1.403-27.102, p = .016).
Our findings show that prediabetes is associated with a poor functional outcome in intracerebral hemorrhage patients 1 month poststroke.
糖尿病前期与脑血管病的功能结局之间的关系存在争议。尚未有研究探讨过糖尿病前期与脑出血患者功能结局之间的关系。我们的研究旨在探讨脑出血患者发病后 1 个月时糖尿病前期与功能结局之间的关系。
在发病后 24 小时内连续纳入 150 名脑出血患者，并对其进行 1 个月的随访。通过空腹血糖、餐后 2 小时血糖和糖化血红蛋白水平将患者分为糖尿病组、糖尿病前期组和非糖尿病组。发病后 1 个月改良 Rankin 量表评分>2 的患者定义为功能结局不良。
与非糖尿病组相比，脑出血患者中糖尿病前期组的功能结局不良风险更高（37.9%比 9.8%，χ²=11.521，p=.001）。经调整混杂因素后的 logistic 回归分析显示，糖尿病前期与脑出血患者发病后 1 个月的功能结局不良相关（比值比=6.167，95%置信区间=1.403-27.102，p=.016）。
本研究结果表明，糖尿病前期与脑出血患者发病后 1 个月的功能结局不良相关。
