Wang Qiongzhang, Zhao Kai, Cai Yan, Tu Xinjie, Liu Yuntao, He Jincai
Wenzhou Medical University, Wenzhou 325000, Zhejiang Province, China.
Wenzhou Medical University, Wenzhou 325000, Zhejiang Province, China.
Brain Res. 2018 May 15;1687:137-143. doi: 10.1016/j.brainres.2017.12.034. Epub 2017 Dec 28.
Diabetes mellitus is associated with post-stroke cognitive impairment. To the best of our knowledge, no study has explored the relationship between prediabetes and post-stroke cognitive impairment. The purpose of this study is to explore the association between prediabetes and cognitive impairment in ischaemic stroke patients at 1 month.
Two hundred one acute ischaemic stroke patients were consecutively recruited within the first 24 h after admission and were followed up for 1 month. Patients were divided into a diabetes mellitus group, prediabetes group and non-diabetes mellitus group by fasting glucose levels, 2-h postprandial blood glucose levels and glycosylated haemoglobin levels at admission. Cognitive function was evaluated by the Mini-Mental State Examination at 1 month after stroke.
The prediabetes group had a higher risk of post-stroke cognitive impairment than the non-diabetes group (35.7% vs. 18.1%, χ = 4.252, P = .039). In logistical analyses, prediabetes was associated with post-stroke cognitive impairment after adjusting for potential confounding factors (odds ratio 3.062, 95% confidence interval 1.130-8.299, P = .028).
Our findings show that prediabetes is associated with post-stroke cognitive impairment and may predict its development at 1 month post-stroke.
糖尿病与卒中后认知障碍相关。据我们所知，尚无研究探讨糖尿病前期与卒中后认知障碍之间的关系。本研究旨在探讨糖尿病前期与缺血性卒中患者1个月时认知障碍之间的关联。
连续纳入201例急性缺血性卒中患者，于入院后24小时内入组，并随访1个月。根据入院时的空腹血糖水平、餐后2小时血糖水平和糖化血红蛋白水平，将患者分为糖尿病组、糖尿病前期组和非糖尿病组。在卒中后1个月时，采用简易精神状态检查表评估认知功能。
糖尿病前期组卒中后认知障碍的风险高于非糖尿病组（35.7%对18.1%，χ=4.252，P=0.039）。在逻辑分析中，在调整潜在混杂因素后，糖尿病前期与卒中后认知障碍相关（比值比3.062，95%置信区间1.130-8.299，P=0.028）。
我们的研究结果表明，糖尿病前期与卒中后认知障碍相关，并可能预测卒中后1个月时其发展情况。
