Centre of Diabetes and Metabolic Diseases, Department of Internal Medicine and Therapeutics, University of Pavia and Fondazione IRCCS Policlinico San Matteo, Pavia, Italy; Centre for Prevention, Surveillance, Diagnosis and Treatment of Rare Diseases, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy; Laboratory of Molecular Medicine, University of Pavia, Pavia, Italy.
Centre of Diabetes and Metabolic Diseases, Department of Internal Medicine and Therapeutics, University of Pavia and Fondazione IRCCS Policlinico San Matteo, Pavia, Italy; Laboratory of Molecular Medicine, University of Pavia, Pavia, Italy.
Nutrition. 2020 May;73:110700. doi: 10.1016/j.nut.2019.110700. Epub 2019 Dec 14.
The aim of this study was to evaluate the effects of undenatured whey protein isolate (WPI; ≥92.5%) with a high content of native cysteine (2.7%) and a standardized content of lactoferrin (≥0.7%) on parameters related to oxidative stress and inflammation in individuals with type 2 diabetes mellitus.
We assigned 120 white patients with type 2 diabetes and glycated hemoglobin ≥6.5% to two groups. The patients were supplemented daily with WPI or placebo for 3 mo. After 3 mo, the markers of oxidation (superoxide dismutase, glutathione peroxidase, glutathione, and reduced glutathione-to-oxidized glutathione ratio) and inflammation (high sensitivity C-reactive protein, interleukin-6, tumor necrosis factor -α, malondialdehyde) were significantly lower in the WPI group than in the placebo group (P < 0.05). The WPI group obtained a significant improvement in the lipid profile and a reduction in fasting plasma glucose compared with baseline and placebo (P < 0.05). No variations of body weight, body mass index or circumferences and metalloproteinase-2 and -9, or soluble receptor for advanced glycation end product were recorded in either groups.
Supplementation with WPI may be useful in patients with diabetes to control fasting glycemia. Moreover, it can help to improve inflammatory and oxidative stress, which play a crucial role in the development of diabetes complications and also in the progression of other chronic diseases.
本研究旨在评估富含天然半胱氨酸（2.7%）和标准化乳铁蛋白（≥0.7%）的未变性乳清蛋白分离物（WPI；≥92.5%）对 2 型糖尿病患者氧化应激和炎症相关参数的影响。
我们将 120 名糖化血红蛋白≥6.5%的白种 2 型糖尿病患者分为两组。患者每天补充 WPI 或安慰剂，持续 3 个月。3 个月后，WPI 组的氧化标志物（超氧化物歧化酶、谷胱甘肽过氧化物酶、谷胱甘肽和还原型谷胱甘肽/氧化型谷胱甘肽比值）和炎症标志物（高敏 C 反应蛋白、白细胞介素-6、肿瘤坏死因子-α、丙二醛）均显著低于安慰剂组（P<0.05）。与基线和安慰剂相比，WPI 组的血脂谱得到显著改善，空腹血糖降低（P<0.05）。两组的体重、体重指数或周径、基质金属蛋白酶-2 和 -9 或晚期糖基化终产物可溶性受体均无变化。
补充 WPI 可能有助于控制糖尿病患者的空腹血糖。此外，它可以帮助改善炎症和氧化应激，这在糖尿病并发症的发展以及其他慢性疾病的进展中起着至关重要的作用。
