器官移植受者中的皮肤鳞状细胞癌。
Cutaneous squamous cell carcinoma in the organ transplant recipient.
机构信息
Department of Dermatology, University of Pittsburgh, 3708 Fifth Ave #5, Pittsburgh, PA 15213, USA; Hillman Cancer Center, University of Pittsburgh Medical Center, 5115 Centre Ave, Pittsburgh, PA 15232, USA.
Department of Medicine, University of Pittsburgh, 3550 Terrace St, Pittsburgh, PA 15261, USA.
出版信息
Oral Oncol. 2020 Apr;103:104562. doi: 10.1016/j.oraloncology.2019.104562. Epub 2020 Feb 14.
Abstract
One in twenty solid organ transplant recipients (SOTRs) will develop a highly morbid or fatal cutaneous carcinoma after transplantation. The majority of these cases develop on the head and neck and may require intervention on the part of dermatology, dermatologic surgery, otolaryngology, transplant medicine, radiation oncology, and medical oncology. In this review, we discuss the problem of cutaneous squamous cell carcinoma (cSCC) in SOTRs as well as the prognostic factors and management strategies to care for this population.
摘要
每 20 个实体器官移植受者（SOTR）中就有 1 个在移植后会患上高度病态或致命的皮肤癌。这些病例大多数发生在头部和颈部，可能需要皮肤科、皮肤科手术、耳鼻喉科、移植医学、放射肿瘤学和肿瘤内科的共同干预。在这篇综述中，我们讨论了 SOTR 中皮肤鳞状细胞癌（cSCC）的问题，以及用于治疗这一人群的预后因素和管理策略。
相似文献
1
Cutaneous squamous cell carcinoma in the organ transplant recipient.器官移植受者中的皮肤鳞状细胞癌。
Oral Oncol. 2020 Apr;103:104562. doi: 10.1016/j.oraloncology.2019.104562. Epub 2020 Feb 14.
2
Cutaneous Squamous Cell Carcinomas in Solid Organ Transplant Recipients Compared With Immunocompetent Patients.实体器官移植受者与免疫功能正常患者的皮肤鳞状细胞癌比较。
JAMA Dermatol. 2018 Jan 1;154(1):60-66. doi: 10.1001/jamadermatol.2017.4506.
3
Sirolimus use and risk of cutaneous squamous cell carcinoma (SCC) in solid organ transplant recipients (SOTRs).西罗莫司的使用与实体器官移植受者（SOTRs）皮肤鳞状细胞癌（SCC）风险的相关性。
J Am Acad Dermatol. 2015 Sep;73(3):444-50. doi: 10.1016/j.jaad.2015.05.029. Epub 2015 Jun 30.
4
Consensus-Based Recommendations on the Prevention of Squamous Cell Carcinoma in Solid Organ Transplant Recipients: A Delphi Consensus Statement.基于共识的实体器官移植受者鳞状细胞癌预防推荐意见：德尔菲共识声明。
JAMA Dermatol. 2021 Oct 1;157(10):1219-1226. doi: 10.1001/jamadermatol.2021.3180.
5
Cumulative incidence and risk factors for cutaneous squamous cell carcinoma metastases in organ transplant recipients: The Skin Care in Organ Transplant Patients in Europe-International Transplant Skin Cancer Collaborative metastases study, a prospective multicenter study.器官移植受者皮肤鳞状细胞癌转移的累积发生率和危险因素：欧洲-国际移植皮肤癌协作组皮肤护理器官移植受者转移研究，一项前瞻性多中心研究。
J Am Acad Dermatol. 2024 Jun;90(6):1200-1209. doi: 10.1016/j.jaad.2024.01.040. Epub 2024 Feb 1.
6
Sebaceous Carcinoma Incidence and Survival Among Solid Organ Transplant Recipients in the United States, 1987-2017.美国 1987-2017 年实体器官移植受者的皮脂腺癌发病和生存情况。
JAMA Dermatol. 2020 Dec 1;156(12):1307-1314. doi: 10.1001/jamadermatol.2020.3111.
7
A case controlled study of risk factors for metastatic squamous cell carcinoma in organ transplant recipients: single academic medical center.器官移植受者转移性鳞状细胞癌危险因素的病例对照研究：单家学术医疗中心。
Arch Dermatol Res. 2024 Sep 11;316(8):612. doi: 10.1007/s00403-024-03284-7.
8
Skin cancer in solid organ transplant recipients: advances in therapy and management: part II. Management of skin cancer in solid organ transplant recipients.实体器官移植受者的皮肤癌：治疗和管理进展：第二部分。实体器官移植受者皮肤癌的管理。
J Am Acad Dermatol. 2011 Aug;65(2):263-279. doi: 10.1016/j.jaad.2010.11.063.
9
rs34567942 a Novel Susceptibility Single Nucleotide Polymorphism for Cutaneous Squamous Cell Carcinoma in Organ Transplant Recipients.rs34567942：器官移植受者皮肤鳞状细胞癌的一种新型易感性单核苷酸多态性
Acta Derm Venereol. 2019 Dec 1;99(13):1303-1304. doi: 10.2340/00015555-3322.
10
Comment on "Sirolimus use and risk of cutaneous squamous cell carcinoma (SCC) in solid organ transplant recipients (SOTRs)".关于“实体器官移植受者（SOTR）中西罗莫司的使用与皮肤鳞状细胞癌（SCC）风险”的评论
J Am Acad Dermatol. 2016 May;74(5):e105-6. doi: 10.1016/j.jaad.2015.11.052.
引用本文的文献
1
Malignant Fungating Wounds in Locally Aggressive Cutaneous Squamous Cell Carcinoma: A Case Series.局部侵袭性皮肤鳞状细胞癌中的恶性溃疡伤口：病例系列
Cureus. 2025 Mar 24;17(3):e81114. doi: 10.7759/cureus.81114. eCollection 2025 Mar.
2
Development of diffuse cutaneous squamous cell carcinoma in situ after chemotherapy for ovarian carcinoma and remission with PD1-inhibitor.卵巢癌化疗后原位弥漫性皮肤鳞状细胞癌的发生及PD1抑制剂治疗后的缓解
Gynecol Oncol Rep. 2024 Oct 11;56:101528. doi: 10.1016/j.gore.2024.101528. eCollection 2024 Dec.
3
Current Advances and Challenges in the Management of Cutaneous Squamous Cell Carcinoma in Immunosuppressed Patients.免疫抑制患者皮肤鳞状细胞癌管理的当前进展与挑战
Cancers (Basel). 2024 Sep 10;16(18):3118. doi: 10.3390/cancers16183118.
4
Primary prophylaxis with mTOR inhibitor enhances T cell effector function and prevents heart transplant rejection during talimogene laherparepvec therapy of squamous cell carcinoma.雷莫芦单抗联合替莫唑胺治疗胶质母细胞瘤的临床疗效及安全性分析
Nat Commun. 2024 Apr 30;15(1):3664. doi: 10.1038/s41467-024-47965-3.
5
Nivolumab + Tacrolimus + Prednisone ± Ipilimumab for Kidney Transplant Recipients With Advanced Cutaneous Cancers.纳武单抗+他克莫司+泼尼松±伊匹单抗用于患有晚期皮肤癌的肾移植受者。
J Clin Oncol. 2024 Mar 20;42(9):1011-1020. doi: 10.1200/JCO.23.01497. Epub 2024 Jan 22.
6
Cemiplimab in Ultra-Octogenarian Patients with Cutaneous Squamous Cell Carcinoma: The Real-Life Experience of a Tertiary Referral Center.西米普利单抗治疗超八旬皮肤鳞状细胞癌患者：三级转诊中心的真实病例经验
Vaccines (Basel). 2023 Sep 18;11(9):1500. doi: 10.3390/vaccines11091500.
7
Liver transplant patient with in-transit squamous cell carcinoma treated with talimogene laherparepvec.接受talimogene laherparepvec治疗的正在转运途中的肝移植鳞状细胞癌患者。
JAAD Case Rep. 2023 Aug 9;40:53-57. doi: 10.1016/j.jdcr.2023.07.033. eCollection 2023 Oct.
8
A Comprehensive Landscape of Malignancy After Double Lung Transplantation.双肺移植后恶性肿瘤的全面概述。
Transpl Int. 2023 Aug 17;36:11552. doi: 10.3389/ti.2023.11552. eCollection 2023.
9
Hsa_circ_0005085 may suppress cutaneous squamous cell carcinoma growth and metastasis through targeting the miR-186-5p/LAMC1 axis.Hsa_circ_0005085 可能通过靶向 miR-186-5p/LAMC1 轴抑制皮肤鳞状细胞癌的生长和转移。
Skin Res Technol. 2023 Jun;29(6):e13321. doi: 10.1111/srt.13321.
10
Human Regulatory T Cells: Understanding the Role of Tregs in Select Autoimmune Skin Diseases and Post-Transplant Nonmelanoma Skin Cancers.人类调节性 T 细胞：了解 Tregs 在特定自身免疫性皮肤疾病和移植后非黑色素瘤皮肤癌中的作用。
Int J Mol Sci. 2023 Jan 12;24(2):1527. doi: 10.3390/ijms24021527.
本文引用的文献
1
Immunity to commensal papillomaviruses protects against skin cancer.对共生型乳头瘤病毒的免疫可预防皮肤癌。
Nature. 2019 Nov;575(7783):519-522. doi: 10.1038/s41586-019-1719-9. Epub 2019 Oct 30.
2
Checkpoint inhibitor therapy for cancer in solid organ transplantation recipients: an institutional experience and a systematic review of the literature.实体器官移植受者中癌症的检查点抑制剂治疗：机构经验和文献系统评价。
J Immunother Cancer. 2019 Apr 16;7(1):106. doi: 10.1186/s40425-019-0585-1.
3
Sentinel lymph node biopsy for high-risk cutaneous squamous cell carcinoma of the head and neck.头颈部高危皮肤鳞状细胞癌前哨淋巴结活检。
Laryngoscope. 2020 Jan;130(1):108-114. doi: 10.1002/lary.27881. Epub 2019 Mar 7.
4
Stratification of Poor Outcomes for Cutaneous Squamous Cell Carcinoma in Immunosuppressed Patients Using the American Joint Committee on Cancer Eighth Edition and Brigham and Women's Hospital Staging Systems.基于美国癌症联合委员会第八版和布莱根妇女医院分期系统对免疫抑制患者皮肤鳞状细胞癌不良结局进行分层。
Dermatol Surg. 2019 Sep;45(9):1117-1124. doi: 10.1097/DSS.0000000000001774.
5
Elective neck dissection in metastatic cutaneous squamous cell carcinoma to the parotid gland: A systematic review and meta-analysis.择期颈清扫术治疗腮腺转移性皮肤鳞状细胞癌：系统评价和荟萃分析。
Head Neck. 2019 Apr;41(4):1131-1139. doi: 10.1002/hed.25561. Epub 2018 Dec 7.
6
Liver Allograft Failure After Nivolumab Treatment-A Case Report With Systematic Literature Research.纳武单抗治疗后肝移植失败——一例报告及系统文献研究
Transplant Direct. 2018 Jul 20;4(8):e376. doi: 10.1097/TXD.0000000000000814. eCollection 2018 Aug.
7
The genomic landscape of cutaneous SCC reveals drivers and a novel azathioprine associated mutational signature.皮肤鳞状细胞癌的基因组特征揭示了驱动因素和一种新型的巯嘌呤相关突变特征。
Nat Commun. 2018 Sep 10;9(1):3667. doi: 10.1038/s41467-018-06027-1.
8
Comparing the eighth and the seventh editions of the American Joint Committee on Cancer staging system and the Brigham and Women's Hospital alternative staging system for cutaneous squamous cell carcinoma: Implications for clinical practice.比较第八版和第七版美国癌症联合委员会分期系统与布莱根妇女医院皮肤鳞状细胞癌替代分期系统：对临床实践的影响。
J Am Acad Dermatol. 2019 Jan;80(1):106-113.e2. doi: 10.1016/j.jaad.2018.06.060. Epub 2018 Jul 10.
9
Recent advances in field cancerization and management of multiple cutaneous squamous cell carcinomas.皮肤原位癌及多发性皮肤鳞状细胞癌治疗的最新进展
F1000Res. 2018 Jun 1;7. doi: 10.12688/f1000research.12837.1. eCollection 2018.
10
Improved keratinocyte carcinoma outcomes with annual dermatology assessment after solid organ transplantation: Population-based cohort study.实体器官移植后每年进行皮肤科评估可改善角质形成细胞癌结局：基于人群的队列研究。
Am J Transplant. 2019 Feb;19(2):522-531. doi: 10.1111/ajt.14966. Epub 2018 Jul 6.
Zotero 插件