脱髓鞘疾病中的肠脑通讯。
Gut-brain communication in demyelinating disorders.
机构信息
Neuroscience Initiative, Advanced Science Research Center, The Graduate Center at the City University of New York, New York, NY, USA; Graduate Program in Biology, The Graduate Center at the City University of New York, New York, NY, USA.
Neuroscience Initiative, Advanced Science Research Center, The Graduate Center at the City University of New York, New York, NY, USA; Graduate Program in Biology, The Graduate Center at the City University of New York, New York, NY, USA; Program in Biochemistry The Graduate Center at The City University of New York, New York, NY, USA.
出版信息
Curr Opin Neurobiol. 2020 Jun;62:92-101. doi: 10.1016/j.conb.2020.01.005. Epub 2020 Feb 15.
Multiple Sclerosis (MS) is an autoimmune demyelinating disorder resulting from the interplay of genetic predisposition and environmental variables, including gut microbiota, diet and life style factors. Here, we first discuss the evidence supporting the effect of early life events, diet and body mass index on the composition of the microbiota, and then review studies on gut dysbiosis conducted in MS patients and in animal models. We address the effect of disease, immunomodulatory therapies, diet and probiotics on enrichment or depletion of gut microbial species. Finally, we discuss the ability of gut bacteria to produce toxins and metabolites which serve as signals for the cross-talk between the gut and the brain.
多发性硬化症（MS）是一种自身免疫性脱髓鞘疾病，由遗传易感性和环境变量（包括肠道微生物群、饮食和生活方式因素）相互作用引起。在这里，我们首先讨论支持早期生活事件、饮食和体重指数对微生物组组成影响的证据，然后综述 MS 患者和动物模型中进行的肠道微生态失调研究。我们还探讨了疾病、免疫调节治疗、饮食和益生菌对肠道微生物物种丰度的富集或耗竭的影响。最后，我们讨论了肠道细菌产生毒素和代谢物的能力，这些毒素和代谢物可作为肠道和大脑之间相互作用的信号。
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