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临床内镜中伪影检测和分割算法的客观比较。

An objective comparison of detection and segmentation algorithms for artefacts in clinical endoscopy.

机构信息

Institute of Biomedical Engineering, Big Data Institute, Department of Engineering Science, University of Oxford, Oxford, UK.

Ludwig Institute for Cancer Research, University of Oxford, Oxford, UK.

出版信息

Sci Rep. 2020 Feb 17;10(1):2748. doi: 10.1038/s41598-020-59413-5.

DOI:10.1038/s41598-020-59413-5
PMID:32066744
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7026422/
Abstract

We present a comprehensive analysis of the submissions to the first edition of the Endoscopy Artefact Detection challenge (EAD). Using crowd-sourcing, this initiative is a step towards understanding the limitations of existing state-of-the-art computer vision methods applied to endoscopy and promoting the development of new approaches suitable for clinical translation. Endoscopy is a routine imaging technique for the detection, diagnosis and treatment of diseases in hollow-organs; the esophagus, stomach, colon, uterus and the bladder. However the nature of these organs prevent imaged tissues to be free of imaging artefacts such as bubbles, pixel saturation, organ specularity and debris, all of which pose substantial challenges for any quantitative analysis. Consequently, the potential for improved clinical outcomes through quantitative assessment of abnormal mucosal surface observed in endoscopy videos is presently not realized accurately. The EAD challenge promotes awareness of and addresses this key bottleneck problem by investigating methods that can accurately classify, localize and segment artefacts in endoscopy frames as critical prerequisite tasks. Using a diverse curated multi-institutional, multi-modality, multi-organ dataset of video frames, the accuracy and performance of 23 algorithms were objectively ranked for artefact detection and segmentation. The ability of methods to generalize to unseen datasets was also evaluated. The best performing methods (top 15%) propose deep learning strategies to reconcile variabilities in artefact appearance with respect to size, modality, occurrence and organ type. However, no single method outperformed across all tasks. Detailed analyses reveal the shortcomings of current training strategies and highlight the need for developing new optimal metrics to accurately quantify the clinical applicability of methods.

摘要

我们对首届内镜伪影检测挑战赛(EAD)的参赛作品进行了全面分析。通过众包的方式,该计划旨在了解现有的计算机视觉方法在应用于内窥镜检查时的局限性,并推动适合临床转化的新方法的发展。内窥镜检查是一种常规的成像技术,用于检测、诊断和治疗中空器官(食管、胃、结肠、子宫和膀胱)的疾病。然而,这些器官的性质使得成像组织无法避免成像伪影,如气泡、像素饱和、器官镜面反射和碎片等,所有这些都对任何定量分析都构成了实质性的挑战。因此,通过对内窥镜视频中观察到的异常黏膜表面进行定量评估,提高临床效果的潜力目前还没有得到准确实现。EAD 挑战赛通过研究能够准确分类、定位和分割内窥镜图像中的伪影的方法,提高了对此关键瓶颈问题的认识并解决了这一问题,这些方法是进行定量分析的关键前提任务。该挑战赛使用了多样化的、经过精心策划的多机构、多模态、多器官的视频帧数据集,客观地对 23 种算法在伪影检测和分割方面的准确性和性能进行了排名。还评估了这些方法对未见数据集的泛化能力。表现最好的方法(前 15%)提出了深度学习策略,以协调伪影在大小、模态、出现和器官类型方面的可变性。然而,没有一种方法在所有任务中都表现出色。详细的分析揭示了当前训练策略的不足之处,并强调需要开发新的最佳指标来准确地量化方法的临床适用性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39de/7026422/492f10b780dd/41598_2020_59413_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39de/7026422/8a3c2eae81a9/41598_2020_59413_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39de/7026422/196fae3f43ae/41598_2020_59413_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39de/7026422/9b4deba1392c/41598_2020_59413_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39de/7026422/492f10b780dd/41598_2020_59413_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39de/7026422/8a3c2eae81a9/41598_2020_59413_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39de/7026422/196fae3f43ae/41598_2020_59413_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39de/7026422/9b4deba1392c/41598_2020_59413_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39de/7026422/492f10b780dd/41598_2020_59413_Fig4_HTML.jpg

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