Lentis Psychiatric Institute, Center for Integrative Psychiatry, Groningen, Netherlands.
Department of Clinical Psychology and Experimental Psychopathology, University of Groningen, Groningen, Netherlands.
Int J Methods Psychiatr Res. 2020 Jun;29(2):e1820. doi: 10.1002/mpr.1820. Epub 2020 Feb 17.
Despite the gains made by current first-line interventions for major depressive disorder (MDD), modest rates of treatment response and high relapse indicate the need to augment existing interventions. Following theory and initial research indicating the promise of mindful yoga interventions (MYIs), this study examines mindful yoga as a treatment of MDD.
METHODS/DESIGN: This randomized controlled trial uses a sample of young females (18-34 years) to examine the efficacy and cost-effectiveness of a 9-week manualized MYI added to treatment as usual (TAU) versus TAU alone. Primary outcome measures consist of clinician-administered (Hamilton Depression Rating Scale) and self-report (Depression-Anxiety-Stress Scales) measures of depression. Underlying mechanisms will be examined, including rumination, negative self-evaluation, intolerance of uncertainty, interoceptive awareness, and dispositional mindfulness. Assessments were conducted at preintervention and will be conducted at postintervention, 6-, and 12-month follow up.
The baseline sample consists of 171 females (88 were randomized into the MYI), reporting a baseline M = 25.08 years (SD = 4.64), M = 18.39 (SD = 6.00), and a M = 21.02 (SD = 9.36).
This trial will provide important information regarding the benefits of adding yoga-based interventions to TAU for young women with MDD and the mechanisms through which such benefits may occur.
尽管目前针对重度抑郁症（MDD）的一线干预措施取得了进展，但治疗反应率仍较低，复发率较高，这表明需要增强现有的干预措施。在理论和初步研究表明正念瑜伽干预（MYIs）有前景之后，本研究探讨了正念瑜伽作为 MDD 的治疗方法。
方法/设计：这项随机对照试验使用了年轻女性（18-34 岁）的样本，以检验 9 周正念瑜伽干预（包括常规治疗）与常规治疗相比对 MDD 的疗效和成本效益。主要的结果测量包括临床医生评估的（汉密尔顿抑郁量表）和自我报告的（抑郁焦虑压力量表）抑郁测量。将检查包括沉思、消极自我评价、不确定耐受力、内感受意识和倾向正念在内的潜在机制。评估在干预前和干预后、6 个月和 12 个月进行。
基线样本包括 171 名女性（88 名被随机分配到 MYI 组），报告的基线 M = 25.08 岁（SD = 4.64），M = 18.39（SD = 6.00）和 M = 21.02（SD = 9.36）。
这项试验将提供有关在常规治疗中增加基于瑜伽的干预措施对 MDD 年轻女性的益处以及这些益处可能发生的机制的重要信息。
