Vollbehr Nina K, Hoenders H J Rogier, Bartels-Velthuis Agna A, Nauta Maaike H, Castelein Stynke, Schroevers Maya J, Stant A Dennis, Albers Casper J, de Jong Peter J, Ostafin Brian D
Lentis Psychiatric Institute, Center for Integrative Psychiatry.
Department of Clinical Psychology and Experimental Psychopathology.
J Consult Clin Psychol. 2022 Dec;90(12):925-941. doi: 10.1037/ccp0000777.
To examine the added value of a 9-week mindful yoga intervention (MYI) as add-on to treatment as usual (TAU) in reducing depression for young women (18-34 years) with major depressive disorder (MDD).
Randomized controlled trial (RCT; n = 171) comparing TAU + MYI with TAU-only. Assessments were at baseline, postintervention, and at 6- and 12-month follow-up. Primary outcome measures were clinician-rated and self-reported symptoms of depression, together with a diagnostic interview to establish MDD diagnosis that was restricted to the baseline and 12-month follow-up assessments. Quality of life in various domains was assessed as secondary outcome measure. As potential mediators for treatment efficacy, we included self-report measures of rumination, self-criticism, self-compassion, intolerance of uncertainty, perceived body awareness and dispositional mindfulness, together with behavioral measures of attentional bias (AB) and depression-related self-associations.
Adding MYI to TAU did not lead to greater reduction of depression symptoms, lower rate of MDD diagnosis or increase in quality of life in various domains of functioning at post and follow-up assessments. There were no indirect effects through any of the potential mediators, with the exception of self-compassion.
Adding MYI to TAU appeared not more efficacious than TAU-only in reducing depression symptoms in young women. (PsycInfo Database Record (c) 2023 APA, all rights reserved).
探讨为期9周的正念瑜伽干预（MYI）作为常规治疗（TAU）的附加治疗，对患有重度抑郁症（MDD）的年轻女性（18 - 34岁）减轻抑郁症状的附加价值。
随机对照试验（RCT；n = 171），比较TAU + MYI与单纯TAU。评估在基线、干预后、6个月和12个月随访时进行。主要结局指标是临床医生评定和自我报告的抑郁症状，以及用于确定MDD诊断的诊断访谈，该访谈仅限于基线和12个月随访评估。将各领域的生活质量作为次要结局指标进行评估。作为治疗效果的潜在中介因素，我们纳入了反刍、自我批评、自我同情、对不确定性的不耐受、身体感知意识和特质正念的自我报告测量，以及注意偏向（AB）和与抑郁相关的自我联想的行为测量。
在TAU基础上加用MYI，在干预后和随访评估中，并未导致抑郁症状的更大程度减轻、MDD诊断率降低或各功能领域生活质量提高。除自我同情外，通过任何潜在中介因素均未产生间接效应。
在TAU基础上加用MYI，在减轻年轻女性抑郁症状方面似乎并不比单纯TAU更有效。（PsycInfo数据库记录（c）2023美国心理学会，保留所有权利）
