肿痛胺 C 及其衍生物的全合成及抗菌活性研究。
Total Synthesis and Antimicrobial Activity of Tumescenamide C and Its Derivatives.
机构信息
Department of System Chemotherapy and Molecular Sciences, Division of Bioinformatics and Chemical Genomics, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan.
出版信息
J Org Chem. 2020 Mar 20;85(6):4530-4535. doi: 10.1021/acs.joc.9b03516. Epub 2020 Feb 26.
Tumescenamide C () is an antimicrobial compound produced by sp. KUSC_F05 and consists of a cyclic depsipeptide core and a polyketide side chain with branched methyl groups. Here, we report the total synthesis of tumescenamide C and two derivatives, mainly using Fmoc solid-phase peptide synthesis (SPPS). In addition, a biological evaluation of these compounds revealed the critical partial structure in for antimicrobial activity.
肿柄菊素 C () 是一种由 sp. KUSC_F05 产生的抗菌化合物，由一个环状的 depsipeptide 核心和一个带有支链甲基的聚酮侧链组成。在这里，我们主要采用 Fmoc 固相肽合成 (SPPS) 法报道了肿柄菊素 C 及其两种衍生物的全合成。此外，这些化合物的生物评价揭示了 中对抗菌活性起关键作用的部分结构。
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