抗菌肽的化学合成

Chemical Synthesis of Antimicrobial Peptides.

作者信息

Münzker Lena, Oddo Alberto, Hansen Paul R

机构信息

Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, Copenhagen, 2100, Denmark.

出版信息

Methods Mol Biol. 2017;1548:35-49. doi: 10.1007/978-1-4939-6737-7_3.

DOI:10.1007/978-1-4939-6737-7_3

PMID:28013495

Abstract

Solid-phase peptide synthesis (SPPS) is the method of choice for chemical synthesis of peptides. In this nonspecialist review, we describe commonly used resins, linkers, protecting groups, and coupling reagents in 9-fluorenylmethyloxycarbonyl (Fmoc) SPPS. Finally, a detailed protocol for manual Fmoc SPPS is presented.

摘要

固相肽合成（SPPS）是肽化学合成的首选方法。在这篇非专业综述中，我们描述了9-芴甲氧羰基（Fmoc）固相肽合成中常用的树脂、连接体、保护基团和偶联试剂。最后，给出了手动Fmoc固相肽合成的详细方案。