Department of Colorectal Surgery, Fujian Medical University Union Hospital, Fuzhou, Fujian, PR China.
Future Oncol. 2020 Mar;16(8):339-351. doi: 10.2217/fon-2019-0793. Epub 2020 Feb 18.
To explore the impact of preoperative the albumin-to-globulin ratio (AGR) and the prognostic nutritional index (PNI) on prognosis in rectal mucinous adenocarcinoma (MAC). A total of 128 patients were included. According to the X-tile analysis, cutoff values of AGR and PNI were 1.1 and 43.8. Preoperative AGR (p = 0.041), preoperative PNI (p = 0.036) and pTNM stage (p = 0.003) were independently associated with overall survival in rectal MAC patients. Distance from the anal verge (p = 0.005), preoperative AGR (p = 0.021), preoperative PNI (p = 0.007) and pTNM stage (p < 0.001) were significantly associated with disease-free survival in rectal MAC patients. Nomograms for overall survival and disease-free survival were developed (C-index: 0.739 and 0.764). Preoperative AGR and PNI can act as effective predictors for survival for rectal MAC patients.
探讨术前白蛋白与球蛋白比值（AGR）和预后营养指数（PNI）对直肠黏液腺癌（MAC）预后的影响。共纳入 128 例患者。根据 X-tile 分析，AGR 和 PNI 的截断值分别为 1.1 和 43.8。术前 AGR（p=0.041）、术前 PNI（p=0.036）和 pTNM 分期（p=0.003）与直肠 MAC 患者的总生存率独立相关。距肛缘距离（p=0.005）、术前 AGR（p=0.021）、术前 PNI（p=0.007）和 pTNM 分期（p<0.001）与直肠 MAC 患者的无病生存率显著相关。建立了总生存率和无病生存率的列线图（C 指数：0.739 和 0.764）。术前 AGR 和 PNI 可作为预测直肠 MAC 患者生存的有效指标。
