Carregaro Adriano Bonfim, Ueda Giuliana Izumi, Censoni Julia Barrionuevo, Bisetto Shayne Pedrozo, Alonso Bruna Bodini, Reginato Gustavo Morandini
Veterinary Medicine Department, Faculty of Animal Science and Food Engineering, University of Sao Paulo (USP), Pirassununga, SP, Brazil.
Veterinary Medicine Department, Faculty of Animal Science and Food Engineering, University of Sao Paulo (USP), Pirassununga, SP, Brazil.
J Equine Vet Sci. 2020 Mar;86:102908. doi: 10.1016/j.jevs.2019.102908. Epub 2020 Jan 3.
The aim of this study was to compare the effects of methadone combined with detomidine or acepromazine on the quality of sedation and its influence over dissociative anesthesia in healthy horses. In a crossover design, seven horses were administered with 0.1 mg/kg methadone and 0.02 mg/kg detomidine intravenously (group MD) or 0.1 mg/kg methadone and 0.05 mg/kg acepromazine intravenously (group MA). Subsequently, anesthesia was induced with a combination of 2.2 mg/kg ketamine and 0.1 mg/kg midazolam intravenously. Descriptive scales and footages were used to evaluate the quality of sedation, induction, anesthesia maintenance, and recovery. Physiological parameters, arterial blood gas, and electrolytes were assessed from baseline to the recovery of anesthesia. The MA group showed lower arterial blood pressure and higher heart rate compared with the group MD. A slight decrease in arterial blood oxygen levels was observed after recumbency, more prominently in the MA group. There was no difference in the quality or time of induction or maintenance or recovery of anesthesia between groups. The results suggest that both premedication protocols produce good sedation and quality of anesthesia. Methadone combined with detomidine produced a good cardiopulmonary stability compared with methadone combined with acepromazine and might be safer to be used as premedication for dissociative anesthesia compared with methadone combined with acepromazine in healthy horses.
本研究的目的是比较美沙酮联合右美托咪定或乙酰丙嗪对健康马匹镇静质量及其对分离麻醉影响的效果。在交叉设计中，7匹马静脉注射0.1mg/kg美沙酮和0.02mg/kg右美托咪定（MD组）或0.1mg/kg美沙酮和0.05mg/kg乙酰丙嗪（MA组）。随后，静脉注射2.2mg/kg氯胺酮和0.1mg/kg咪达唑仑进行麻醉诱导。使用描述性量表和录像来评估镇静、诱导、麻醉维持和恢复的质量。从基线到麻醉恢复评估生理参数、动脉血气和电解质。与MD组相比，MA组动脉血压较低，心率较高。卧位后观察到动脉血氧水平略有下降，在MA组更明显。两组之间麻醉诱导、维持或恢复的质量或时间没有差异。结果表明，两种术前用药方案均能产生良好的镇静效果和麻醉质量。与美沙酮联合乙酰丙嗪相比，美沙酮联合右美托咪定在健康马匹中产生了良好的心肺稳定性，并且作为分离麻醉的术前用药可能比美沙酮联合乙酰丙嗪更安全。
