Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, United Kingdom; Children's Neurosciences Department, Evelina London Children's Hospital, Guy's and St Thomas NHS Foundation Trust, London, United Kingdom.
Department of Informatics, King's College London, United Kingdom.
Clin Neurophysiol. 2020 Apr;131(4):967-977. doi: 10.1016/j.clinph.2020.01.012. Epub 2020 Feb 4.
Sensorimotor processing is abnormal in Idiopathic/Genetic dystonias, but poorly studied in Acquired dystonias. Beta-Corticomuscular coherence (CMC) quantifies coupling between oscillatory electroencephalogram (EEG) and electromyogram (EMG) activity and is modulated by sensory stimuli. We test the hypothesis that sensory modulation of CMC and intermuscular coherence (IMC) is abnormal in Idiopathic/Genetic and Acquired dystonias.
Participants: 11 children with Acquired dystonia, 5 with Idiopathic/Genetic dystonia, 13 controls (12-18 years). CMC and IMC were recorded during a grasp task, with mechanical perturbations provided by an electromechanical tapper. Coherence patterns pre- and post-stimulus were compared across groups.
Beta-CMC increased post-stimulus in Controls and Acquired dystonia (p = 0.001 and p = 0.010, respectively), but not in Idiopathic/Genetic dystonia (p = 0.799). The modulation differed between groups, being larger in both Controls and Acquired dystonia compared with Idiopathic/Genetic dystonia (p = 0.003 and p = 0.022). Beta-IMC increased significantly post-stimulus in Controls (p = 0.004), but not in dystonia. Prominent 4-12 Hz IMC was seen in all dystonia patients and correlated with severity (rho = 0.618).
Idiopathic/Genetic and Acquired dystonia share an abnormal low-frequency IMC. In contrast, sensory modulation of beta-CMC differed between the two groups.
The findings suggest that sensorimotor processing is abnormal in Acquired as well as Idiopathic/Genetic dystonia, but that the nature of the abnormality differs.
感觉运动处理在特发性/遗传性运动障碍中异常，但在获得性运动障碍中研究甚少。β-皮质肌束相干性（CMC）量化了脑电图（EEG）和肌电图（EMG）活动之间的耦合，并受感觉刺激的调节。我们检验了这样一个假设，即特发性/遗传性和获得性运动障碍中的 CMC 和肌间相干性（IMC）的感觉调制是异常的。
参与者：11 名获得性运动障碍儿童，5 名特发性/遗传性运动障碍儿童，13 名对照者（12-18 岁）。在抓握任务期间记录 CMC 和 IMC，由机电敲击器提供机械扰动。在刺激前后比较各组的相干模式。
β-CMC 在对照组和获得性运动障碍中刺激后增加（p=0.001 和 p=0.010），但在特发性/遗传性运动障碍中不增加（p=0.799）。这种调制在各组之间不同，在对照组和获得性运动障碍中均大于特发性/遗传性运动障碍（p=0.003 和 p=0.022）。β-IMC 在对照组中显著增加（p=0.004），但在运动障碍中不增加。所有运动障碍患者都出现了明显的 4-12Hz IMC，并与严重程度相关（rho=0.618）。
特发性/遗传性和获得性运动障碍具有共同的异常低频 IMC。相比之下，β-CMC 的感觉调制在两组之间存在差异。
这些发现表明，获得性和特发性/遗传性运动障碍都存在感觉运动处理异常，但异常的性质不同。
