Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE5 9RX, United Kingdom.
Medical Research Council Brain Network Dynamics Unit and Nuffield, Department of Clinical Neurosciences, University of Oxford, Oxford OX1 3TH, United Kingdom.
Neuroimage Clin. 2021;30:102569. doi: 10.1016/j.nicl.2021.102569. Epub 2021 Jan 19.
Dystonia is a disorder of sensorimotor integration associated with abnormal oscillatory activity within the basal ganglia-thalamo-cortical networks. Event-related changes in spectral EEG activity reflect cortical processing but are sparsely investigated in relation to sensorimotor processing in dystonia. This study investigates modulation of sensorimotor cortex EEG activity in response to a proprioceptive stimulus in children with dystonia and dystonic cerebral palsy (CP). Proprioceptive stimuli, comprising brief stretches of the wrist flexors, were delivered via a robotic wrist interface to 30 young people with dystonia (20 isolated genetic/idiopathic and 10 dystonic CP) and 22 controls (mean age 12.7 years). Scalp EEG was recorded using the 10-20 international system and the relative change in post-stimulus power with respect to baseline was calculated for the alpha (8-12 Hz) and beta (14-30 Hz) frequency bands. A clear developmental profile in event-related spectral changes was seen in controls. Controls showed a prominent early alpha/mu band event-related desynchronisation (ERD) followed by an event-related synchronisation (ERS) over the contralateral sensorimotor cortex following movement of either hand. The alpha ERD was significantly smaller in the dystonia groups for both dominant and non-dominant hand movement (ANCOVA across the 3 groups with age as covariate: dominant hand F(2,47) = 4.45 p = 0.017; non-dominant hand F(2,42) = 9.397 p < 0.001. Alpha ERS was significantly smaller in dystonia for the dominant hand (ANCOVA F(2,47) = 7.786 p = 0.001). There was no significant difference in ERD or ERS between genetic/idiopathic dystonia and dystonic CP. CONCLUSION: Modulation of alpha/mu activity by a proprioceptive stimulus is reduced in dystonia, demonstrating a developmental abnormality of sensorimotor processing which is common to isolated genetic/idiopathic and acquired dystonia/dystonic CP.
肌张力障碍是一种与基底节-丘脑-皮质网络中异常振荡活动相关的感觉运动整合障碍。事件相关的频谱 EEG 活动变化反映了皮质处理过程，但在与肌张力障碍的感觉运动处理相关的研究中很少被研究。本研究调查了儿童肌张力障碍和肌张力障碍性脑瘫（CP）患者对本体感受刺激的感觉运动皮层 EEG 活动的调制。本体感受刺激包括腕屈肌的短暂伸展，通过机器人腕部接口传递给 30 名患有肌张力障碍的年轻人（20 名孤立的遗传/特发性和 10 名肌张力障碍 CP）和 22 名对照者（平均年龄 12.7 岁）。头皮 EEG 使用 10-20 国际系统记录，计算相对于基线的刺激后功率的相对变化，用于 alpha（8-12 Hz）和 beta（14-30 Hz）频段。在对照组中，观察到事件相关光谱变化的清晰发育特征。对照组在手部运动时，表现出明显的早期 alpha/mu 波段事件相关去同步化（ERD），随后对侧感觉运动皮层出现事件相关同步化（ERS）。对于优势手和非优势手运动，两组肌张力障碍组的 alpha ERD 明显较小（3 组之间的 ANCOVA 与年龄作为协变量：优势手 F（2,47）= 4.45 p = 0.017；非优势手 F（2,42）= 9.397 p < 0.001。对于优势手，肌张力障碍患者的 alpha ERS 明显较小（ANCOVA F（2,47）= 7.786 p = 0.001）。遗传/特发性肌张力障碍与肌张力障碍 CP 之间的 ERD 或 ERS 无显著差异。结论：本体感受刺激引起的 alpha/mu 活动的调制在肌张力障碍中减少，表明感觉运动处理的发育异常，这种异常在孤立的遗传/特发性和获得性肌张力障碍/肌张力障碍 CP 中是共同的。
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