Cine State Hospital, Aydin, Turkey; Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Ege University, Bornova, Izmir, Turkey.
Department of Neurosurgery, Faculty of Medicine, Ege University, Izmir, Turkey.
J Glob Antimicrob Resist. 2020 Sep;22:147-151. doi: 10.1016/j.jgar.2020.02.001. Epub 2020 Feb 14.
The aim of this study was to compare the antibacterial activity of ceftaroline versus vancomycin in the treatment of methicillin-resistant Staphylococcus aureus (MRSA) meningitis in an experimental rabbit meningitis model.
The antibacterial activity of ceftaroline was compared with vancomycin in the treatment of meningitis induced by MRSA strain ATCC 43300 in an experimental rabbit meningitis model. Quantitative cerebrospinal fluid (CSF) cultures were performed at the beginning of antibiotic treatment and 24h and 73h after the first antibiotic dose. Furthermore, in vitro time-kill data were investigated at 0, 2, 4, 6, 8, 12 and 24h in sterile human serum.
The difference between the control group versus both treatment groups was significant when comparing the decrease in colony counts in CSF both at 24h and 73h after the first antibiotic dose (P<0.05). At the end of the experiment, there was a significant difference in survival between both the ceftaroline-treated group and the vancomycin-treated group versus the control group, but not between the two treatment groups.
These results suggest that the antibacterial activity of both ceftaroline and vancomycin are similar in the treatment of MRSA meningitis in an experimental rabbit meningitis model.
本研究旨在比较头孢洛林与万古霉素治疗耐甲氧西林金黄色葡萄球菌（MRSA）性脑膜炎的抗菌活性，采用兔实验性脑膜炎模型。
采用耐甲氧西林金黄色葡萄球菌 ATCC 43300 株诱导兔实验性脑膜炎模型，比较头孢洛林与万古霉素治疗脑膜炎的抗菌活性。在抗生素治疗开始时、首次用药后 24h 和 73h 进行定量脑脊液（CSF）培养。此外，在无菌人血清中于 0、2、4、6、8、12 和 24h 进行体外时间杀伤数据研究。
与对照组相比，首次抗生素治疗后 24h 和 73h CSF 中菌落计数减少，两组治疗组差异均有统计学意义（P<0.05）。实验结束时，头孢洛林组和万古霉素组的存活率与对照组相比均有显著差异，但两组之间无差异。
这些结果表明，头孢洛林和万古霉素在兔实验性脑膜炎模型中治疗耐甲氧西林金黄色葡萄球菌性脑膜炎的抗菌活性相似。
