Department of Biomedical Engineering, Michigan Technological University, Houghton, Michigan 49931, United States.
School of Environmental Science and Engineering, Guangdong University of Technology, Guangzhou 510006, China.
ACS Appl Mater Interfaces. 2020 May 13;12(19):21210-21220. doi: 10.1021/acsami.9b19726. Epub 2020 Feb 18.
Reactive oxygen species (ROS) can degrade organic compounds and function as a broad-spectrum disinfectant. Here, dopamine methacrylamide (DMA) was used to prepare catechol-containing microgels, which can release ROS via metal-catechol interaction. A combination of the microgel and iron magnetic nanoparticle (FeMNP) significantly reduced the concentration of four organic dyes (Alizarin Red S, Rhodamine B, Crystal Violet, and Malachite Green) and an antibiotic drug, ciprofloxacin, dissolved in solution. Degradation of dye occurred across a wide range of pH levels (pH 3-9). This simple combination was also antimicrobial against both and . Electron paramagnetic resonance spectroscopy (EPR) results indicate that singlet oxygen was generated during the reaction between catechol and FeMNP at both pH 3 and 7.4, which was responsible for the degradation of organic compounds and bactericidal features of the microgel. Unlike autoxidation that only occurs at a neutral to basic pH, FeMNP-induced catechol oxidation generated singlet oxygen over a wide range of pH level. Additionally, catechol chelates heavy metal ions, resulting in their removal from solution and repurposed these metal ions for dye degradation. This multifunctional microgel can potentially be used for environmental applications for the removal of organic pollutants and heavy metal ions from wastewater, as well as reducing bacterial infection in biomedical applications.
活性氧 (ROS) 可以降解有机化合物，并作为广谱消毒剂发挥作用。在这里，使用多巴胺甲基丙烯酰胺 (DMA) 制备了含有儿茶酚的微凝胶，通过金属-儿茶酚相互作用可以释放 ROS。微凝胶与铁磁性纳米颗粒 (FeMNP) 的组合显著降低了溶解在溶液中的四种有机染料（茜素红 S、罗丹明 B、结晶紫和孔雀石绿）和一种抗生素药物环丙沙星的浓度。在广泛的 pH 值范围内（pH 3-9）发生了染料降解。这种简单的组合还对 和 具有抗菌作用。电子顺磁共振波谱 (EPR) 结果表明，在 pH 3 和 7.4 下，儿茶酚与 FeMNP 之间的反应产生了单线态氧，这是导致有机化合物降解和微凝胶杀菌特性的原因。与仅在中性至碱性 pH 下发生的自动氧化不同，FeMNP 诱导的儿茶酚氧化在广泛的 pH 范围内产生单线态氧。此外，儿茶酚螯合重金属离子，从而将其从溶液中去除，并重新利用这些金属离子进行染料降解。这种多功能微凝胶可用于环境应用，从废水中去除有机污染物和重金属离子，并在生物医学应用中减少细菌感染。
