Tamayo Lizeth I, Lin Hannah, Ahmed Alauddin, Shahriar Hasan, Hasan Rabiul, Sarwar Golam, Eunus Hem Mahbubul, Ahsan Habibul, Pierce Brandon L
Department of Public Health Sciences, The University of Chicago, Chicago, Illinois, USA.
University of Chicago Research Bangladesh, Dhaka, Bangladesh.
Public Health Genomics. 2020;23(1-2):69-76. doi: 10.1159/000505632. Epub 2020 Feb 18.
In human genetics research, it has become common practice for researchers to consider returning genetic information to participants who wish to receive it. Research participants in lower-resource settings may have barriers or competing interests that reduce the benefit or relevance of such information. Thus, the decision to return genetic information in these settings may involve special considerations of participants' interests and preferences. In this project, our goal was to assess Bangladeshi research participants' attitudes towards receiving information regarding genetic susceptibility to the effects of consuming arsenic-contaminated drinking water, a serious environmental health concern in Bangladesh and other countries.
We administered a short questionnaire to 200 individuals participating in the Health Effects of Arsenic Longitudinal Study. Associations between survey responses and participant characteristics were estimated using logistic regression.
Overall, 100% of our participants were interested in receiving information regarding their genetic susceptibility to arsenic toxicities, and 91% indicated that being at increased genetic risk would motivate them to make efforts to reduce their exposure. Lower levels of education showed evidence of association with less concern regarding the health effects of arsenic and lower levels of motivation to reduce exposure in response to genetic information.
Research participants in this low-resource setting appeared interested in receiving information on their genetic susceptibility to arsenic toxicity and motivated to reduce exposure in response to such information. Additional research is needed to understand how best to communicate genetic information in this population and to assess the impact of such information on individuals' behaviors and health.
在人类遗传学研究中，研究人员向希望获取遗传信息的参与者反馈遗传信息已成为一种常见做法。资源匮乏地区的研究参与者可能存在障碍或相互冲突的利益，这会降低此类信息的益处或相关性。因此，在这些地区反馈遗传信息的决定可能需要特别考虑参与者的利益和偏好。在本项目中，我们的目标是评估孟加拉国研究参与者对于获取有关饮用受砷污染饮用水影响的遗传易感性信息的态度，这是孟加拉国和其他国家严重的环境卫生问题。
我们向200名参与砷的健康影响纵向研究的个体发放了一份简短问卷。使用逻辑回归估计调查回复与参与者特征之间的关联。
总体而言，100%的参与者有兴趣获取有关其对砷毒性遗传易感性的信息，91%的参与者表示遗传风险增加会促使他们努力减少接触。教育程度较低表明与对砷的健康影响关注较少以及因遗传信息而减少接触的动机较低有关。
在这个资源匮乏地区的研究参与者似乎有兴趣获取有关其对砷毒性遗传易感性的信息，并愿意因此类信息而减少接触。需要进一步研究以了解如何最好地向该人群传达遗传信息，并评估此类信息对个人行为和健康的影响。
