Llido John Paul, Jayanti Sri, Tiribelli Claudio, Gazzin Silvia
Liver Brain Unit "Rita Moretti", Italian Liver Foundation, Bldg. Q, AREA Science Park, Basovizza, 34149 Trieste, Italy.
Department of Science and Technology, Philippine Council for Health Research and Development, Bicutan, Taguig City 1631, Philippines.
Antioxidants (Basel). 2023 Jul 29;12(8):1525. doi: 10.3390/antiox12081525.
Cellular redox status has a crucial role in brain physiology, as well as in pathologic conditions. Physiologic senescence, by dysregulating cellular redox homeostasis and decreasing antioxidant defenses, enhances the central nervous system's susceptibility to diseases. The reduction of free radical accumulation through lifestyle changes, and the supplementation of antioxidants as a prophylactic and therapeutic approach to increase brain health, are strongly suggested. Bilirubin is a powerful endogenous antioxidant, with more and more recognized roles as a biomarker of disease resistance, a predictor of all-cause mortality, and a molecule that may promote health in adults. The alteration of the expression and activity of the enzymes involved in bilirubin production, as well as an altered blood bilirubin level, are often reported in neurologic conditions and neurodegenerative diseases (together denoted NCDs) in aging. These changes may predict or contribute both positively and negatively to the diseases. Understanding the role of bilirubin in the onset and progression of NCDs will be functional to consider the benefits vs. the drawbacks and to hypothesize the best strategies for its manipulation for therapeutic purposes.
细胞氧化还原状态在脑生理学以及病理状况中都起着至关重要的作用。生理衰老通过失调细胞氧化还原稳态并降低抗氧化防御能力，增强了中枢神经系统对疾病的易感性。强烈建议通过改变生活方式减少自由基积累，并补充抗氧化剂作为预防和治疗手段以增进脑健康。胆红素是一种强大的内源性抗氧化剂，其作为疾病抵抗力的生物标志物、全因死亡率的预测指标以及可能促进成年人健康的分子，所起的作用越来越受到认可。在衰老过程中的神经疾病和神经退行性疾病（统称为非传染性疾病，NCDs）中，经常会报告胆红素生成相关酶的表达和活性改变以及血胆红素水平改变。这些变化可能对疾病产生正向或负向的预测或影响。了解胆红素在非传染性疾病的发生和发展中的作用，将有助于权衡其利弊，并推测出用于治疗目的对其进行调控的最佳策略。
