Department of Ophthalmology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan.
Department of Ophthalmology, National Defense Medical College, Saitama, Japan.
BMC Ophthalmol. 2020 Feb 18;20(1):56. doi: 10.1186/s12886-020-01334-y.
Previously, we showed that serum malondialdehyde (MDA) was significantly higher in patients with neovascular age-related macular degeneration (nAMD) than in those without AMD. The Diacron reactive oxygen metabolites (d-ROMs) and biological antioxidant potential (BAP) tests are known markers of oxidative stress. The aim of this study was to use d-ROMs and BAP tests to evaluate changes in systemic oxidative stress in patients with nAMD.
Blood serum samples were collected from 34 patients with nAMD (mean age: 76.5 ± 7.7 years; 22 men) and 20 control subjects (mean age: 62.9 ± 14.0 years; 10 men), and d-ROMs and BAP tests were examined.
In men, the mean level of d-ROMs for the nAMD patients was significantly higher than that for the controls (312.0 ± 52.4 vs. 275.1 ± 45.5 U.CARR, respectively; P < .05). There was a significant correlation between d-ROM level and CNV lesion area in the male nAMD group (r = .42, P = .05). There were no significant differences in mean BAP test results between the nAMD patients and controls for either sex (men: 2241 ± 549 vs. 2136 ± 246 μmol/L; women: 2263 ± 292 vs. 2335 ± 161 μmol/L).
The d-ROMs test may provide a useful indicator of nAMD in men but not in women.
此前，我们发现新生血管性年龄相关性黄斑变性（nAMD）患者的血清丙二醛（MDA）显著高于非 AMD 患者。Diacron 活性氧代谢物（d-ROMs）和生物抗氧化潜力（BAP）测试是已知的氧化应激标志物。本研究旨在使用 d-ROMs 和 BAP 测试评估 nAMD 患者全身氧化应激的变化。
采集 34 名 nAMD 患者（平均年龄：76.5±7.7 岁；22 名男性）和 20 名对照者（平均年龄：62.9±14.0 岁；10 名男性）的血清样本，并检测 d-ROMs 和 BAP 测试。
在男性中，nAMD 患者的 d-ROMs 平均值明显高于对照组（分别为 312.0±52.4 和 275.1±45.5 U.CARR；P<.05）。nAMD 男性组中 d-ROM 水平与 CNV 病变面积之间存在显著相关性（r=.42，P=.05）。nAMD 患者和对照组的平均 BAP 测试结果在两性之间均无显著差异（男性：2241±549 与 2136±246 μmol/L；女性：2263±292 与 2335±161 μmol/L）。
d-ROMs 测试可能是男性 nAMD 的有用指标，但对女性则不然。
