Department of Pediatrics, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, 600 Yishan road, Shanghai, China.
China Hospital Development Institute, Shanghai Jiao Tong University, Shanghai, China.
Respir Res. 2020 Feb 18;21(1):57. doi: 10.1186/s12931-020-1318-1.
We aimed to identify the prevalence and distribution patterns of allergens among Chinese children with asthma/asthma-like symptoms (ALS).
A total of 3479 children with asthma/ALS were enrolled. Skin prick test (SPT) was used to test the allergen-specific IgE. We analysed allergens prevalence and distribution, and its relationship with demographic characteristics.
Aeroallergens prevalence was higher than that of food allergens (p < 10). Boys had higher aeroallergens prevalence than that in girls (p < 10). Significant difference of aeroallergens prevalence among cases with different parental allergy history was observed (p < 10). Age was positively associated with aeroallergens prevalence before the age of 11.5 (P < 10), particularly before the age of 2.42 (P < 10). Age was negatively associated with aeroallergens prevalence after the age of 11.5 (P = 0.021). Age was negatively associated with food allergens prevalence before the age of 3.42 (P < 10). Age was associated with the intensity of dermatophagoides farinae (DF)/house dust mite (HDM) allergens (P < 10). Age was negatively associated with the intensity of shrimp, and crab allergens before the age of 3.3 and 3.3, respectively (P = 0.012, < 10). Boys had higher intensity of DF and HDM allergens than that in girls (P < 10, P < 10). Significant differences of the intensity of DF and HDM allergens among groups with different parental allergy history were noted (P < 10, P < 10).
Boys and parental allergy history were associated with higher prevalence and intenstity of aeroallergens. Age was positively and negatively associated with aeroallergens prevalence before and after the age of 11.5, respectively. Age was negatively associated with food allergens prevalence before the age of 3.42.
我们旨在确定中国哮喘/哮喘样症状（ALS）儿童的过敏原流行率和分布模式。
共纳入 3479 例哮喘/ALS 患儿。采用皮肤点刺试验（SPT）检测过敏原特异性 IgE。分析过敏原的流行率和分布，及其与人口统计学特征的关系。
气传过敏原的流行率高于食物过敏原（p<0.01）。男孩的气传过敏原流行率高于女孩（p<0.01）。不同父母过敏史患儿的气传过敏原流行率存在显著差异（p<0.01）。11.5 岁前，年龄与气传过敏原流行率呈正相关（P<0.01），特别是在 2.42 岁之前（P<0.01）。11.5 岁后，年龄与气传过敏原流行率呈负相关（P=0.021）。3.42 岁前，年龄与食物过敏原流行率呈负相关（P<0.01）。年龄与粉尘螨/屋尘螨（HDM）过敏原的强度相关（P<0.01）。3.3 岁前，年龄与虾和蟹过敏原的强度呈负相关（P=0.012，P<0.01）。男孩的粉尘螨和 HDM 过敏原强度高于女孩（P<0.01，P<0.01）。不同父母过敏史患儿的粉尘螨和 HDM 过敏原强度存在显著差异（P<0.01，P<0.01）。
男孩和父母过敏史与气传过敏原的高流行率和强度相关。11.5 岁前，年龄与气传过敏原流行率呈正相关，11.5 岁后，年龄与气传过敏原流行率呈负相关。3.42 岁前，年龄与食物过敏原流行率呈负相关。
