Bengtsson C, Lapidus L, Stendahl C, Waldenström J
Department of Primary Health Care, Gothenburg University, Sweden.
Acta Med Scand. 1988;224(6):549-55.
Serum uric concentration was determined in a series of 1462 women, aged 38-60 when first examined in 1968-69, as the first phase of a longitudinal population study in Gothenburg, Sweden. Serum uric acid concentration was positively correlated to the 12-year overall mortality in univariate analysis. No relationship was observed between initial serum uric acid values and incidence of myocardial infarction, angina pectoris, ECG changes indicating ischaemic heart disease or stroke. The association between serum uric acid concentration and mortality was independent of age, body mass index, systolic blood pressure, adipose tissue distribution, smoking habits, serum cholesterol concentration, serum triglyceride concentration, serum creatinine concentration, serum calcium concentration, use of diuretics, and haematological disease. The increased mortality could not be explained by any increase in malignant neoplastic disease.
在瑞典哥德堡进行的一项纵向人群研究的第一阶段，对1968 - 1969年首次接受检查时年龄在38 - 60岁的1462名女性测定了血清尿酸浓度。在单变量分析中，血清尿酸浓度与12年的总死亡率呈正相关。未观察到初始血清尿酸值与心肌梗死、心绞痛、提示缺血性心脏病的心电图变化或中风发生率之间存在关联。血清尿酸浓度与死亡率之间的关联独立于年龄、体重指数、收缩压、脂肪组织分布、吸烟习惯、血清胆固醇浓度、血清甘油三酯浓度、血清肌酐浓度、血清钙浓度、利尿剂的使用以及血液系统疾病。死亡率的增加无法用恶性肿瘤疾病的任何增加来解释。
