University of Dschang, Dschang, Cameroon.
University of Cape Town, Groote Schuur Hospital, Cape Town, South Africa.
Pan Afr Med J. 2021 Nov 22;40:177. doi: 10.11604/pamj.2021.40.177.30207. eCollection 2021.
given the difficulty to obtain glycemic control in type 2 diabetes, the exploration of others pathophysiological hypotheses could improve the understanding of this phenomenon. We conducted this study to search for an association between uric acid and uncontrolled diabetes.
it was a cross-sectional study in a population of type 2 diabetes with normal postprandial and fast blood sugar for the last three months at the District Hospital of Dschang. Chi square test were used to analyzed categorical variables and Pearson correlation coefficient to evaluate the relationship between uric acid level and HbA1c. Means were compared using Kruskal-Walli's or Student's test.
our study of 80 patients found that, female sex and central obesity were risk factors for hyperuricemia. Prevalence of hyperuricemia and uncontrolled diabetes was respectively 27.5% and 33.8%. The proportion of women with hyperuricemia was significantly higher than that of men (59.1% versus 40.9%, p=0.021) and this inequality of proportion was more marked particularly after 45 years (40% versus 18.8%, p=0.022). Hyperuricemia was not significantly associated to uncontrolled diabetes (OR=2.01 IC (0.73-5.52), p=0.095). Serum uric acid was positively and significantly correlated to glycated hemoglobin (r=0.318, p=0.002) and hyperuricemia was significantly correlated to uncontrolled diabetes (r=0.712, p=0.035). The mean of glycated hemoglobin is abnormal (7.14%) when uric acid level is around 5.75 mg/dl without sex distinction.
these results suggest that the rate of glycated hemoglobin is associated to serum uric acid variations during type 2 diabetes.
鉴于 2 型糖尿病患者很难控制血糖，探索其他病理生理假说可以帮助我们更好地理解这一现象。我们进行了这项研究，旨在寻找尿酸与未控制糖尿病之间的关联。
这是一项横断面研究，研究对象为 80 名在 Dschang 区医院最近三个月餐后和空腹血糖正常的 2 型糖尿病患者。卡方检验用于分析分类变量，Pearson 相关系数用于评估尿酸水平与 HbA1c 之间的关系。使用 Kruskal-Walli 或 Student 检验比较均值。
我们的研究发现，女性和中心性肥胖是高尿酸血症的危险因素。高尿酸血症和未控制糖尿病的患病率分别为 27.5%和 33.8%。高尿酸血症女性患者的比例明显高于男性（59.1%比 40.9%，p=0.021），这种比例的不平等在 45 岁以后更为明显（40%比 18.8%，p=0.022）。高尿酸血症与未控制糖尿病无显著相关性（OR=2.01，95%CI（0.73-5.52），p=0.095）。血清尿酸与糖化血红蛋白呈正相关（r=0.318，p=0.002），高尿酸血症与未控制糖尿病呈显著相关（r=0.712，p=0.035）。当尿酸水平在 5.75mg/dl 左右时，无论性别如何，糖化血红蛋白的平均值均异常（7.14%）。
这些结果表明，在 2 型糖尿病中，糖化血红蛋白的水平与血清尿酸的变化有关。
