ARF/ARL 家族基因在子宫内膜癌中的临床相关性及 ARL4C 的致癌功能。
Clinical relevance of ARF/ARL family genes and oncogenic function of ARL4C in endometrial cancer.
机构信息
Department of Obstetrics and Gynecology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiaotong University, Shanghai, China.
出版信息
Biomed Pharmacother. 2020 May;125:110000. doi: 10.1016/j.biopha.2020.110000. Epub 2020 Feb 25.
Members of ADP-ribosylation factor (ARF)/ARF-like protein (ARL) family regulate malignant phenotype of cancer cells. The present study aims to investigate the clinical relevance of ARF/ARL family members in endometrial cancer. We report that several ARF/ARL family genes serve as prognostic biomarkers for endometrial cancer. Through a combination of TCGA database and immunohistochemistry analysis, we revealed that ARL4C, a member of ARL family, was overexpressed in endometrial cancer and might function as an oncogene in endometrial carcinogenesis. Gene set enrichment analysis (GSEA) and functional studies demonstrated that cell cycle and cell adhesion pathways were the potential mechanism of ARL4C in promoting endometrial cancer cell proliferation, migration and invasion. Moreover, we also observed the involvement of ARL4C in metformin-inhibited cellular proliferation of endometrial cancer. Collectively, knowledge of the expression and function of ARF/ARL family genes could provide a potential therapeutic strategy for endometrial cancer.
ADP-核糖基化因子（ARF）/ARF 样蛋白（ARL）家族成员调节癌细胞的恶性表型。本研究旨在探讨 ARF/ARL 家族成员在子宫内膜癌中的临床相关性。我们报告称，ARF/ARL 家族的几个基因可作为子宫内膜癌的预后生物标志物。通过 TCGA 数据库和免疫组织化学分析，我们揭示了 ARL4C，ARL 家族的一员，在子宫内膜癌中过表达，并可能在子宫内膜癌发生中作为癌基因发挥作用。基因集富集分析（GSEA）和功能研究表明，细胞周期和细胞黏附途径可能是 ARL4C 促进子宫内膜癌细胞增殖、迁移和侵袭的潜在机制。此外，我们还观察到 ARL4C 参与二甲双胍抑制子宫内膜癌细胞增殖。总之，对 ARF/ARL 家族基因的表达和功能的了解可能为子宫内膜癌提供一种潜在的治疗策略。
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