Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, New York, USA
Br J Ophthalmol. 2020 Nov;104(11):1488-1491. doi: 10.1136/bjophthalmol-2019-314583. Epub 2020 Feb 18.
Studies have confirmed that optic disc haemorrhage (ODH) is a significant risk factor for the development and progression of primary open-angle glaucoma (POAG). Various populations have differing risk factors for developing POAG. As such, a literature review was conducted examining seven studies published in India, China, Japan, Australia, Korea and the USA. The goal of this review was to better identify ODH risk factors and their relationship to development and progression of POAG. Ultimately, patients with ODH have a greater risk for developing POAG across all populations analysed in this review. However, some populations demonstrated additional risk factors for ODH, such as increasing age and female gender. Paradoxically, data from several studies show that people of African descent have a reduced risk of ODH despite having increased risk of open-angle glaucoma than their Caucasian counterparts. By parsing out the complex relations between ODH and open-angle glaucoma stratified by age, gender and race, we may gain a broader understanding of glaucoma pathogenesis and derive individualised treatment strategies.
研究证实，视盘出血（ODH）是原发性开角型青光眼（POAG）发展和进展的重要危险因素。不同人群发生 POAG 的危险因素也不同。因此，对发表在印度、中国、日本、澳大利亚、韩国和美国的 7 项研究进行了文献回顾。本综述的目的是更好地确定 ODH 的危险因素及其与 POAG 发展和进展的关系。最终，本综述分析的所有人群中，ODH 患者发生 POAG 的风险更高。然而，一些人群显示出 ODH 的其他危险因素，例如年龄增长和女性性别。矛盾的是，几项研究的数据表明，尽管非裔人群患开角型青光眼的风险高于白种人，但他们患 ODH 的风险较低。通过按年龄、性别和种族对 ODH 和开角型青光眼之间的复杂关系进行细分，我们可能会更全面地了解青光眼的发病机制，并制定个体化的治疗策略。
