他汀类药物用于神经发育障碍临床治疗开发的考量因素。 - Suppr

Considerations for Clinical Therapeutic Development of Statins for Neurodevelopmental Disorders.

作者信息

Ottenhoff Myrthe J, Krab Lianne C, Elgersma Ype

机构信息

Department of Neuroscience, ENCORE Expertise Center for Neurodevelopmental Disorders, Erasmus Medical Center, 3015 GD, Rotterdam, The Netherlands.

Cordaan Outpatient Clinic for ID Medicine, 1033 PK, Amsterdam.

出版信息

eNeuro. 2020 Mar 6;7(2). doi: 10.1523/ENEURO.0392-19.2020. Print 2020 Mar/Apr.

DOI:10.1523/ENEURO.0392-19.2020

PMID:32071072

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7070444/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/02f2/7070444/4b158a07277f/SN-ENUJ200032F001.jpg

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Residual effects of lovastatin and simvastatin on urinary mevalonate excretions in patients with familial hypercholesterolemia.洛伐他汀和辛伐他汀对家族性高胆固醇血症患者尿中甲羟戊酸排泄的残留影响。

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FTIR spectroscopic study of two isostructural statins: Simvastatin and Lovastatin as authentic and in pharmaceuticals.傅里叶变换红外光谱法研究两种结构相同的他汀类药物：辛伐他汀和洛伐他汀作为正品和药物。

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Low-density lipoprotein cholesterol (LDL-C) levels and LDL-C goal attainment among elderly patients treated with rosuvastatin compared with other statins in routine clinical practice.在常规临床实践中，与其他他汀类药物相比，瑞舒伐他汀治疗的老年患者的低密度脂蛋白胆固醇（LDL-C）水平及LDL-C达标情况。

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Mechanism of action and biological profile of HMG CoA reductase inhibitors. A new therapeutic alternative.HMG CoA还原酶抑制剂的作用机制及生物学特性。一种新的治疗选择。

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Lovastatin and simvastatin--inhibitors of HMG CoA reductase and cholesterol biosynthesis.洛伐他汀和辛伐他汀——HMG CoA还原酶抑制剂及胆固醇生物合成抑制剂。

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Considerations for Clinical Therapeutic Development of Statins for Neurodevelopmental Disorders.

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