过氧化氢对妊娠大鼠子宫前列腺素生成及收缩的影响。

Effect of hydrogen peroxide on prostaglandin production and contractions of the pregnant rat uterus.

作者信息

Cherouny P H, Ghodgaonkar R B, Niebyl J R, Dubin N H

机构信息

Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD 21205.

出版信息

Am J Obstet Gynecol. 1988 Dec;159(6):1390-4. doi: 10.1016/0002-9378(88)90562-5.

DOI:10.1016/0002-9378(88)90562-5

PMID:3207115

Abstract

Although evidence for a role for prostaglandins in parturition is abundant, less is known about how prostaglandin levels are regulated at term. Conditions occurring peripartum in the uteroplacental unit can result in reactive oxygen production. We investigated the effect of one reactive oxygen product, hydrogen peroxide, on in vitro activity of uterine segments from the 18-day-pregnant rat. H2O2 (0.3 mmol/L) was found to elicit rhythmic contractions and increase prostaglandins F2 alpha and E2 release by uterine tissue. Indomethacin blocked both of these effects. We conclude that H2O2 stimulates uterine contractions through a prostaglandin release mechanism. A speculative hypothesis of peripartum regulation of prostaglandin production by reactive oxygen is discussed.

摘要

尽管前列腺素在分娩过程中发挥作用的证据确凿，但对于足月时前列腺素水平是如何调节的，人们了解得较少。子宫胎盘单位在围产期出现的状况可导致活性氧的产生。我们研究了一种活性氧产物过氧化氢对妊娠18天大鼠子宫段体外活性的影响。发现过氧化氢（0.3 mmol/L）可引发节律性收缩，并增加子宫组织中前列腺素F2α和E2的释放。吲哚美辛可阻断这两种效应。我们得出结论，过氧化氢通过前列腺素释放机制刺激子宫收缩。文中还讨论了关于活性氧对围产期前列腺素产生进行调节的一个推测性假说。