氨茶碱对体外培养的妊娠大鼠子宫平滑肌收缩性及前列腺素生成的影响。

The effect of aminophylline on uterine smooth muscle contractility and prostaglandin production in the pregnant rat uterus in vitro.

作者信息

Laifer S A, Ghodgaonkar R B, Zacur H A, Dubin N H

出版信息

Am J Obstet Gynecol. 1986 Jul;155(1):212-5. doi: 10.1016/0002-9378(86)90113-4.

Abstract

The effect of aminophylline on contractility and prostaglandin production was investigated in a 20-day pregnant rat uterus preparation in vitro. A significant decrease was observed in frequency (24.4% of control, p less than 0.05) and contractile force (13.8% of control, p less than 0.001) in rat uterine segments treated with aminophylline. Treated segments produced more prostaglandin E2 (139.6% of control, p less than 0.001) and less prostaglandin F2 alpha (73.8% of control, p less than 0.001) during the 45-minute observation period. No significant difference in thromboxane B2 or 6-ketoprostaglandin F1 alpha production was noted. This is the first observation of prostaglandin levels in rat uterine segments treated with aminophylline. It could not be concluded from this study whether the observed changes in prostaglandin production are directly related to the relaxant effect of aminophylline.

摘要

在体外对20日龄妊娠大鼠子宫制备物研究了氨茶碱对收缩性和前列腺素产生的影响。在用氨茶碱处理的大鼠子宫节段中，观察到频率（为对照的24.4%，p<0.05）和收缩力（为对照的13.8%，p<0.001）显著降低。在45分钟观察期内，处理过的节段产生更多的前列腺素E2（为对照的139.6%，p<0.001）和更少的前列腺素F2α（为对照的73.8%，p<0.001）。血栓素B2或6-酮前列腺素F1α产生方面未观察到显著差异。这是首次观察氨茶碱处理的大鼠子宫节段中的前列腺素水平。从本研究无法得出观察到的前列腺素产生变化是否与氨茶碱的松弛作用直接相关的结论。