Shukla A, Sharda B, Sharma S, Bhardwaj S, Kailash U, Kalani R, Satyanarayana L, Shrivastava A
Department of Biochemistry, Rajiv Gandhi Super Specialty Hospital, Dilshad Garden, New Delhi, 110093 India.
2Department of Urology, RG Stone Urology and Laparoscopy Hospital, F-12, East of Kailash, New Delhi, 110065 India.
Indian J Clin Biochem. 2020 Jan;35(1):127-131. doi: 10.1007/s12291-018-0785-3. Epub 2018 Jul 31.
Serum prostatic specific antigen (PSA) and serum testosterone levels share an undefined relationship with each other, with many conflicting studies showing both positive and negative correlation between them. Our aim was to assess association between serum PSA and serum testosterone in healthy men with normal testosterone levels and men with partial androgen deficiency (PADAM). A cross sectional study was conducted at a teaching hospital setting where serum testosterone and aging male symptom scale (AMS) scores along with PSA were studied in 255 men (> 50 years) with and without PADAM. Mean total testosterone and serum PSA was 9.35 ± 1.33 nmol/L, 1.96 ± 0.76 ng/mL in males with PADAM and 15.30 ± 1.95 nmol/L, 1.85 ± 0.73 ng/mL respectively in males without PADAM. No significant relationship was observed between serum PSA and serum testosterone levels among healthy males irrespective of PADAM in the study population. We suggest, there is no need to adjust PSA values for biopsy decisions according to testosterone levels.
血清前列腺特异性抗原（PSA）与血清睾酮水平之间的关系尚不明确，许多相互矛盾的研究表明它们之间存在正相关和负相关。我们的目的是评估睾酮水平正常的健康男性和部分雄激素缺乏（PADAM）男性的血清PSA与血清睾酮之间的关联。在一家教学医院进行了一项横断面研究，对255名年龄大于50岁、有或无PADAM的男性进行了血清睾酮、老年男性症状量表（AMS）评分以及PSA的研究。有PADAM的男性平均总睾酮和血清PSA分别为9.35±1.33nmol/L、1.96±0.76ng/mL，无PADAM的男性分别为15.30±1.95nmol/L、1.85±0.73ng/mL。在研究人群中，无论是否患有PADAM，健康男性的血清PSA与血清睾酮水平之间均未观察到显著关系。我们建议，在进行活检决策时，无需根据睾酮水平调整PSA值。
