使用患者自身血液治疗手足骨关节炎：富血小板血浆的系统评价和荟萃分析
Treating hand and foot osteoarthritis using a patient's own blood: A systematic review and meta-analysis of platelet-rich plasma.
作者信息
Evans Adam, Ibrahim Maryo, Pope Rand, Mwangi James, Botros Mina, Johnson Shepard P, Al Kassis Salam
机构信息
Meharry Medical College, 1005 Dr DB Todd Jr Blvd, Nashville, TN, 37208, USA.
Vanderbilt University School of Medicine, 1161 21st Ave South, Nashville, TN, 37232, USA.
出版信息
J Orthop. 2020 Jan 28;18:226-236. doi: 10.1016/j.jor.2020.01.037. eCollection 2020 Mar-Apr.
Abstract
BACKGROUND
This study summarizes all literature investigating platelet-rich plasma (PRP) in the treatment of osteoarthritis of the hands and feet.
MATERIALS & METHODS: This is a PRISMA compliant systematic review of 7 databases and includes a meta-analysis of randomized controlled trial (RCT) data on pain and function.
RESULTS
Nine articles were included in the review. Meta-analysis of 4 RCTs shows PRP significantly improves pain and function versus control. More results are significant at longer duration follow-up.
CONCLUSIONS
PRP improves pain and function of osteoarthritis. Heterogeneity and risk-of-bias limit current data, requiring more RCTs to determine any regenerative potential of PRP.
PROSPERO SYSTEMATIC REVIEW REGISTRATION NUMBER
摘要
背景
本研究总结了所有关于富血小板血浆（PRP）治疗手足骨关节炎的文献。
材料与方法
这是一项符合PRISMA标准的对7个数据库的系统评价，并对疼痛和功能的随机对照试验（RCT）数据进行荟萃分析。
结果
该评价纳入了9篇文章。对4项RCT的荟萃分析表明，与对照组相比，PRP能显著改善疼痛和功能。在更长时间的随访中，更多结果具有显著性。
结论
PRP可改善骨关节炎的疼痛和功能。异质性和偏倚风险限制了当前数据，需要更多RCT来确定PRP的任何再生潜力。
PROSPERO系统评价注册号：136582。
相似文献
1
Treating hand and foot osteoarthritis using a patient's own blood: A systematic review and meta-analysis of platelet-rich plasma.使用患者自身血液治疗手足骨关节炎：富血小板血浆的系统评价和荟萃分析
J Orthop. 2020 Jan 28;18:226-236. doi: 10.1016/j.jor.2020.01.037. eCollection 2020 Mar-Apr.
2
The temporal effect of platelet-rich plasma on pain and physical function in the treatment of knee osteoarthritis: systematic review and meta-analysis of randomized controlled trials.富血小板血浆治疗膝骨关节炎时对疼痛和身体功能的时间效应：随机对照试验的系统评价和荟萃分析
J Orthop Surg Res. 2017 Jan 23;12(1):16. doi: 10.1186/s13018-017-0521-3.
3
Intra-articular platelet-rich plasma injections versus intra-articular corticosteroid injections for symptomatic management of knee osteoarthritis: systematic review and meta-analysis.关节内富血小板血浆注射与关节内皮质类固醇注射治疗膝关节骨关节炎症状的疗效比较：系统评价和荟萃分析。
BMC Musculoskelet Disord. 2021 Jun 16;22(1):550. doi: 10.1186/s12891-021-04308-3.
4
Platelet-Rich plasma Injection Management for Ankle osteoarthritis study (PRIMA): protocol of a Dutch multicentre, stratified, block-randomised, double-blind, placebo-controlled trial.富血小板血浆注射治疗踝关节骨关节炎的研究（PRIMA）：一项荷兰多中心、分层、区组随机、双盲、安慰剂对照试验方案。
BMJ Open. 2019 Oct 7;9(10):e030961. doi: 10.1136/bmjopen-2019-030961.
5
Single intra-articular injection with or without intra-osseous injections of platelet-rich plasma in the treatment of osteoarthritis knee: A single-blind, randomized clinical trial.单关节内注射或联合骨内注射富血小板血浆治疗膝关节骨关节炎：一项单盲、随机临床试验。
Injury. 2022 Mar;53(3):1247-1253. doi: 10.1016/j.injury.2022.01.012. Epub 2022 Jan 7.
6
Is platelet-rich plasma effective for the treatment of knee osteoarthritis? A systematic review and meta-analysis of level 1 and 2 randomized controlled trials.富血小板血浆治疗膝骨关节炎有效吗？1 级和 2 级随机对照试验的系统评价和荟萃分析。
Eur J Orthop Surg Traumatol. 2020 Aug;30(6):955-967. doi: 10.1007/s00590-020-02623-4. Epub 2020 Feb 14.
7
Intra-articular platelet-rich plasma vs corticosteroids in the treatment of moderate knee osteoarthritis: a single-center prospective randomized controlled study with a 1-year follow up.关节内富血小板血浆与皮质类固醇治疗中度膝骨关节炎：一项单中心前瞻性随机对照研究，随访 1 年。
J Orthop Surg Res. 2020 Jul 10;15(1):257. doi: 10.1186/s13018-020-01753-z.
8
Rejuvenating the periorbital area using platelet-rich plasma: a systematic review and meta-analysis.使用富血小板血浆恢复眶周区域活力：一项系统评价和荟萃分析。
Arch Dermatol Res. 2021 Nov;313(9):711-727. doi: 10.1007/s00403-020-02173-z. Epub 2021 Jan 12.
9
Effects and safety of the combination of platelet-rich plasma (PRP) and hyaluronic acid (HA) in the treatment of knee osteoarthritis: a systematic review and meta-analysis.富血小板血浆（PRP）与透明质酸（HA）联合治疗膝关节骨关节炎的效果及安全性：一项系统评价和荟萃分析
BMC Musculoskelet Disord. 2020 Apr 11;21(1):224. doi: 10.1186/s12891-020-03262-w.
10
The efficacy of intra-articular injections in the treatment of knee osteoarthritis: A network meta-analysis of randomized controlled trials.关节内注射治疗膝骨关节炎的疗效：一项随机对照试验的网络荟萃分析。
Knee. 2021 Oct;32:173-182. doi: 10.1016/j.knee.2021.08.008. Epub 2021 Sep 6.
引用本文的文献
1
Safety and efficacy of platelet-rich plasma injections in basal thumb osteoarthritis; should we offer it or not?富血小板血浆注射治疗拇指基底节骨关节炎的安全性和有效性；我们是否应该采用这种治疗方法？
J Hand Microsurg. 2025 Feb 8;17(3):100223. doi: 10.1016/j.jham.2025.100223. eCollection 2025 May.
2
High-concentrated platelet-rich plasma (PRP) versus placebo in osteoarthritis in the thumb base: study protocol for an assessor-blinded randomized controlled trial.高浓度富血小板血浆（PRP）与安慰剂治疗拇指基底骨关节炎的比较：一项评估者盲法随机对照试验研究方案。
Trials. 2024 Nov 26;25(1):797. doi: 10.1186/s13063-024-08636-2.
3
Platelet-derived chemokines promote skeletal muscle regeneration by guiding neutrophil recruitment to injured muscles.血小板衍生趋化因子通过引导中性粒细胞募集到受损肌肉来促进骨骼肌再生。
Nat Commun. 2023 May 22;14(1):2900. doi: 10.1038/s41467-023-38624-0.
4
Platelet-rich plasma injection for the treatment of ankle osteoarthritis: a systematic review and meta-analysis.富血小板血浆注射治疗踝关节骨关节炎：系统评价和荟萃分析。
J Orthop Surg Res. 2023 May 19;18(1):373. doi: 10.1186/s13018-023-03828-z.
5
Platelet-rich plasma treatment for talar cartilage repair: a systematic review and meta-analysis.富血小板血浆治疗距骨软骨修复：系统评价和荟萃分析。
BMC Musculoskelet Disord. 2023 May 9;24(1):366. doi: 10.1186/s12891-023-06466-y.
6
Safety and efficacy of intra-articular injection of platelet-rich plasma for the treatment of ankle osteoarthritis: a systematic review and meta-analysis.关节内注射富血小板血浆治疗踝骨关节炎的安全性和有效性：系统评价和荟萃分析。
Int Orthop. 2023 Aug;47(8):1963-1974. doi: 10.1007/s00264-023-05773-2. Epub 2023 Mar 21.
7
Challenges and opportunities of pharmacological interventions for osteoarthritis: A review of current clinical trials and developments.骨关节炎药物干预的挑战与机遇：当前临床试验及进展综述
Osteoarthr Cartil Open. 2021 Sep 8;3(4):100212. doi: 10.1016/j.ocarto.2021.100212. eCollection 2021 Dec.
8
PRP Enriched with Hyaluronic Acid -PRP from Rat Protocol and Method of Preparation.富含透明质酸的富血小板血浆——大鼠富血小板血浆的制备方案与方法
Curr Health Sci J. 2021 Jan-Mar;47(1):42-48. doi: 10.12865/CHSJ.47.01.07. Epub 2021 Mar 31.
9
Intraovarian injection of platelet-rich plasma in assisted reproduction: too much too soon?卵巢内注射富含血小板血浆在辅助生殖中的应用：是否操之过急？
Hum Reprod. 2021 Jun 18;36(7):1737-1750. doi: 10.1093/humrep/deab106.
10
New Trends in Injection-Based Therapy for Thumb-Base Osteoarthritis: Where Are We and where Are We Going?拇指基底关节骨关节炎注射治疗的新趋势：我们现状如何，又将走向何方？
Front Pharmacol. 2021 Apr 13;12:637904. doi: 10.3389/fphar.2021.637904. eCollection 2021.
本文引用的文献
1
Analysis of "old" proteins unmasks dynamic gradient of cartilage turnover in human limbs.分析“旧”蛋白质揭示了人类四肢软骨周转率的动态梯度。
Sci Adv. 2019 Oct 9;5(10):eaax3203. doi: 10.1126/sciadv.aax3203. eCollection 2019 Oct.
2
Development of Autologous Platelet-Rich Plasma Mixed-Microfat as an Advanced Therapy Medicinal Product for Intra-Articular Injection of Radio-Carpal Osteoarthritis: From Validation Data to Preliminary Clinical Results.富自体血小板混合微脂作为一种关节内注射桡腕关节炎的高级治疗药物产品的开发：从验证数据到初步临床结果。
Int J Mol Sci. 2019 Mar 5;20(5):1111. doi: 10.3390/ijms20051111.
3
Autologous platelet-rich gel for facial rejuvenation and wrinkle amelioration: A pilot study.自体富血小板凝胶用于面部年轻化和皱纹改善：一项初步研究。
J Cosmet Dermatol. 2019 Oct;18(5):1353-1360. doi: 10.1111/jocd.12823. Epub 2018 Nov 18.
4
Autologous pure platelet-rich plasma injections for facial skin rejuvenation: Biometric instrumental evaluations and patient-reported outcomes to support antiaging effects.自体富血小板血浆注射用于面部皮肤年轻化：支持抗衰老效果的生物计量仪器评估和患者报告结果。
J Cosmet Dermatol. 2019 Aug;18(4):985-995. doi: 10.1111/jocd.12802. Epub 2018 Oct 23.
5
Platelet-Rich Plasma versus Corticosteroid Intra-Articular Injections for the Treatment of Trapeziometacarpal Arthritis: A Prospective Randomized Controlled Clinical Trial.富血小板血浆与皮质类固醇关节内注射治疗腕掌关节炎：一项前瞻性随机对照临床试验。
Cartilage. 2021 Jan;12(1):51-61. doi: 10.1177/1947603518805230. Epub 2018 Oct 20.
6
Combining microneedling with other minimally invasive procedures for facial rejuvenation: a split-face comparative study.微针与其他微创面部年轻化技术联合应用：一项对照研究。
Int J Dermatol. 2018 Nov;57(11):1324-1334. doi: 10.1111/ijd.14172. Epub 2018 Aug 13.
7
Neurologic complications in common wrist and hand surgical procedures.常见手腕及手部外科手术中的神经并发症。
Orthop Rev (Pavia). 2018 Mar 29;10(1):7355. doi: 10.4081/or.2018.7355.
8
Population prevalence and distribution of ankle pain and symptomatic radiographic ankle osteoarthritis in community dwelling older adults: A systematic review and cross-sectional study.社区居住的老年人踝关节疼痛和症状性放射学踝关节骨关节炎的流行率和分布：系统评价和横断面研究。
PLoS One. 2018 Apr 30;13(4):e0193662. doi: 10.1371/journal.pone.0193662. eCollection 2018.
9
Prevention and treatment of low back pain: evidence, challenges, and promising directions.预防和治疗下腰痛：证据、挑战和有前途的方向。
Lancet. 2018 Jun 9;391(10137):2368-2383. doi: 10.1016/S0140-6736(18)30489-6. Epub 2018 Mar 21.
10
Current concepts in treatment of early knee osteoarthritis and osteochondral lesions; the role of biological augmentations.早期膝关节骨关节炎和骨软骨损伤治疗的当前概念；生物增强的作用。
Acta Biomed. 2017 Oct 18;88(4S):5-10. doi: 10.23750/abm.v88i4-S.6788.
Zotero 插件