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使用患者自身血液治疗手足骨关节炎：富血小板血浆的系统评价和荟萃分析

Treating hand and foot osteoarthritis using a patient's own blood: A systematic review and meta-analysis of platelet-rich plasma.

作者信息

Evans Adam, Ibrahim Maryo, Pope Rand, Mwangi James, Botros Mina, Johnson Shepard P, Al Kassis Salam

机构信息

Meharry Medical College, 1005 Dr DB Todd Jr Blvd, Nashville, TN, 37208, USA.

Vanderbilt University School of Medicine, 1161 21st Ave South, Nashville, TN, 37232, USA.

出版信息

J Orthop. 2020 Jan 28;18:226-236. doi: 10.1016/j.jor.2020.01.037. eCollection 2020 Mar-Apr.

DOI:10.1016/j.jor.2020.01.037
PMID:32071509
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7015825/
Abstract

BACKGROUND

This study summarizes all literature investigating platelet-rich plasma (PRP) in the treatment of osteoarthritis of the hands and feet.

MATERIALS & METHODS: This is a PRISMA compliant systematic review of 7 databases and includes a meta-analysis of randomized controlled trial (RCT) data on pain and function.

RESULTS

Nine articles were included in the review. Meta-analysis of 4 RCTs shows PRP significantly improves pain and function versus control. More results are significant at longer duration follow-up.

CONCLUSIONS

PRP improves pain and function of osteoarthritis. Heterogeneity and risk-of-bias limit current data, requiring more RCTs to determine any regenerative potential of PRP.

PROSPERO SYSTEMATIC REVIEW REGISTRATION NUMBER

摘要

背景

本研究总结了所有关于富血小板血浆（PRP）治疗手足骨关节炎的文献。

材料与方法

这是一项符合PRISMA标准的对7个数据库的系统评价，并对疼痛和功能的随机对照试验（RCT）数据进行荟萃分析。

结果

该评价纳入了9篇文章。对4项RCT的荟萃分析表明，与对照组相比，PRP能显著改善疼痛和功能。在更长时间的随访中，更多结果具有显著性。

结论

PRP可改善骨关节炎的疼痛和功能。异质性和偏倚风险限制了当前数据，需要更多RCT来确定PRP的任何再生潜力。

PROSPERO系统评价注册号：136582。

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2
Development of Autologous Platelet-Rich Plasma Mixed-Microfat as an Advanced Therapy Medicinal Product for Intra-Articular Injection of Radio-Carpal Osteoarthritis: From Validation Data to Preliminary Clinical Results.富自体血小板混合微脂作为一种关节内注射桡腕关节炎的高级治疗药物产品的开发：从验证数据到初步临床结果。
Int J Mol Sci. 2019 Mar 5;20(5):1111. doi: 10.3390/ijms20051111.
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Autologous platelet-rich gel for facial rejuvenation and wrinkle amelioration: A pilot study.自体富血小板凝胶用于面部年轻化和皱纹改善：一项初步研究。
J Cosmet Dermatol. 2019 Oct;18(5):1353-1360. doi: 10.1111/jocd.12823. Epub 2018 Nov 18.
4
Autologous pure platelet-rich plasma injections for facial skin rejuvenation: Biometric instrumental evaluations and patient-reported outcomes to support antiaging effects.自体富血小板血浆注射用于面部皮肤年轻化：支持抗衰老效果的生物计量仪器评估和患者报告结果。
J Cosmet Dermatol. 2019 Aug;18(4):985-995. doi: 10.1111/jocd.12802. Epub 2018 Oct 23.
5
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Cartilage. 2021 Jan;12(1):51-61. doi: 10.1177/1947603518805230. Epub 2018 Oct 20.
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Combining microneedling with other minimally invasive procedures for facial rejuvenation: a split-face comparative study.微针与其他微创面部年轻化技术联合应用：一项对照研究。
Int J Dermatol. 2018 Nov;57(11):1324-1334. doi: 10.1111/ijd.14172. Epub 2018 Aug 13.
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Neurologic complications in common wrist and hand surgical procedures.常见手腕及手部外科手术中的神经并发症。
Orthop Rev (Pavia). 2018 Mar 29;10(1):7355. doi: 10.4081/or.2018.7355.
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Population prevalence and distribution of ankle pain and symptomatic radiographic ankle osteoarthritis in community dwelling older adults: A systematic review and cross-sectional study.社区居住的老年人踝关节疼痛和症状性放射学踝关节骨关节炎的流行率和分布：系统评价和横断面研究。
PLoS One. 2018 Apr 30;13(4):e0193662. doi: 10.1371/journal.pone.0193662. eCollection 2018.
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Prevention and treatment of low back pain: evidence, challenges, and promising directions.预防和治疗下腰痛：证据、挑战和有前途的方向。
Lancet. 2018 Jun 9;391(10137):2368-2383. doi: 10.1016/S0140-6736(18)30489-6. Epub 2018 Mar 21.
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Current concepts in treatment of early knee osteoarthritis and osteochondral lesions; the role of biological augmentations.早期膝关节骨关节炎和骨软骨损伤治疗的当前概念；生物增强的作用。
Acta Biomed. 2017 Oct 18;88(4S):5-10. doi: 10.23750/abm.v88i4-S.6788.