早期膝关节骨关节炎和骨软骨损伤治疗的当前概念；生物增强的作用。
Current concepts in treatment of early knee osteoarthritis and osteochondral lesions; the role of biological augmentations.
作者信息
Dall'Oca C, Cengarle M, Costanzo A, Giannini N, Vacchiano A, Magnan B
机构信息
.
出版信息
Acta Biomed. 2017 Oct 18;88(4S):5-10. doi: 10.23750/abm.v88i4-S.6788.
Abstract
Early knee osteoarthritis and chondral lesions are a common cause of disability in younger patients. Surgical options, such as microfractures, ACI and OAT, provide good, but not fully satisfying, outcomes. Recent advance in biological knowledge introduced two different methodological approaches of delivering growth factors and stem cells into the articular environment. Platelet-Rich Plasma and Mesenchimal Stem Cells are supposed to change the way to approach early knee osteoarthritis and chondral lesions, though their indications and limits are yet to be determined.
摘要
早期膝关节骨关节炎和软骨损伤是年轻患者致残的常见原因。手术选择，如微骨折、自体软骨细胞移植和骨软骨移植，能带来较好但并不完全令人满意的效果。生物学知识的最新进展引入了两种将生长因子和干细胞输送到关节环境中的不同方法。富血小板血浆和间充质干细胞有望改变早期膝关节骨关节炎和软骨损伤的治疗方式，不过它们的适应症和局限性还有待确定。
相似文献
1
Current concepts in treatment of early knee osteoarthritis and osteochondral lesions; the role of biological augmentations.早期膝关节骨关节炎和骨软骨损伤治疗的当前概念；生物增强的作用。
Acta Biomed. 2017 Oct 18;88(4S):5-10. doi: 10.23750/abm.v88i4-S.6788.
2
Intra-articular injections of expanded mesenchymal stem cells with and without addition of platelet-rich plasma are safe and effective for knee osteoarthritis.关节内注射扩增间充质干细胞联合（或不联合）富含血小板血浆治疗膝骨关节炎是安全有效的。
Knee Surg Sports Traumatol Arthrosc. 2018 Nov;26(11):3342-3350. doi: 10.1007/s00167-018-4883-9. Epub 2018 Mar 6.
3
Intra-articular Injection of Mesenchymal Stem Cells and Platelet-Rich Plasma to Treat Patellofemoral Osteoarthritis: Preliminary Results of a Long-Term Pilot Study.关节腔内注射间充质干细胞和富血小板血浆治疗髌股关节骨关节炎：一项长期试点研究的初步结果
J Vasc Interv Radiol. 2017 Dec;28(12):1708-1713. doi: 10.1016/j.jvir.2017.08.004. Epub 2017 Oct 12.
4
Platelet-Rich Plasma for the Management of Hip and Knee Osteoarthritis.富血小板血浆用于髋膝关节骨关节炎的治疗
Curr Rheumatol Rep. 2017 May;19(5):24. doi: 10.1007/s11926-017-0652-x.
5
Alternative and complementary therapies in osteoarthritis and cartilage repair.骨关节炎和软骨修复中的替代和补充疗法。
Aging Clin Exp Res. 2020 Apr;32(4):547-560. doi: 10.1007/s40520-020-01515-1. Epub 2020 Mar 13.
6
Matrix-induced autologous mesenchymal stem cell implantation versus matrix-induced autologous chondrocyte implantation in the treatment of chondral defects of the knee: a 2-year randomized study.基质诱导自体间充质干细胞植入与基质诱导自体软骨细胞植入治疗膝关节软骨缺损的2年随机研究。
Arch Orthop Trauma Surg. 2015 Feb;135(2):251-263. doi: 10.1007/s00402-014-2136-z. Epub 2014 Dec 30.
7
Intra-articular injection of photo-activated platelet-rich plasma in patients with knee osteoarthritis: a double-blind, randomized controlled pilot study.膝关节骨关节炎患者关节腔内注射光激活富血小板血浆：一项双盲、随机对照试验性研究
BMC Musculoskelet Disord. 2016 Feb 9;17:67. doi: 10.1186/s12891-016-0920-3.
8
Use of Platelet-Rich Plasma in Intra-Articular Knee Injections for Osteoarthritis: A Systematic Review.富血小板血浆在膝关节骨关节炎关节内注射中的应用：一项系统评价
PM R. 2015 Jun;7(6):637-48. doi: 10.1016/j.pmrj.2015.02.003. Epub 2015 Feb 14.
9
Biologic Therapies for the Treatment of Knee Osteoarthritis.生物制剂治疗膝骨关节炎。
J Arthroplasty. 2019 Apr;34(4):801-813. doi: 10.1016/j.arth.2018.12.001. Epub 2018 Dec 17.
10
Does Intra-articular Platelet-Rich Plasma Injection Provide Clinically Superior Outcomes Compared With Other Therapies in the Treatment of Knee Osteoarthritis? A Systematic Review of Overlapping Meta-analyses.与其他疗法相比，关节腔内注射富血小板血浆在治疗膝关节骨关节炎方面是否能提供更优的临床疗效？对重叠荟萃分析的系统评价。
Arthroscopy. 2015 Nov;31(11):2213-21. doi: 10.1016/j.arthro.2015.03.041. Epub 2015 May 29.
引用本文的文献
1
The treatment of knee cartilage lesions: state of the art.膝关节软骨病变的治疗：最新进展。
Acta Biomed. 2022 Aug 31;93(4):e2022099. doi: 10.23750/abm.v93i4.11740.
2
Microarray analysis of hub genes and pathways in damaged cartilage tissues of knee.膝关节损伤软骨组织中枢纽基因和通路的基因芯片分析。
Medicine (Baltimore). 2021 Sep 17;100(37):e27183. doi: 10.1097/MD.0000000000027183.
3
Research advances in cartilage stem cells markers and induced differentiation.软骨干细胞标志物及诱导分化的研究进展。
Hua Xi Kou Qiang Yi Xue Za Zhi. 2021 Feb 1;39(1):108-114. doi: 10.7518/hxkq.2021.01.017.
4
Treating hand and foot osteoarthritis using a patient's own blood: A systematic review and meta-analysis of platelet-rich plasma.使用患者自身血液治疗手足骨关节炎：富血小板血浆的系统评价和荟萃分析
J Orthop. 2020 Jan 28;18:226-236. doi: 10.1016/j.jor.2020.01.037. eCollection 2020 Mar-Apr.
5
Therapeutic efficacy of extracorporeal shock wave combined with hyaluronic acid on knee osteoarthritis.体外冲击波联合透明质酸治疗膝骨关节炎的疗效
Medicine (Baltimore). 2019 Feb;98(8):e14589. doi: 10.1097/MD.0000000000014589.
6
Efficacy of Duohuojisheng decoction monotherapy for the treatment of knee osteoarthritis: A protocol of a systematic review of randomized controlled trials.独活寄生汤单药治疗膝骨关节炎的疗效：一项随机对照试验系统评价方案
Medicine (Baltimore). 2019 Feb;98(7):e14510. doi: 10.1097/MD.0000000000014510.
7
Mesenchymal Stem Cells injection in hip osteoarthritis: preliminary results.间充质干细胞注射治疗髋骨关节炎：初步结果。
Acta Biomed. 2019 Jan 10;90(1-S):75-80. doi: 10.23750/abm.v90i1-S.8084.
本文引用的文献
1
A Cost-Effectiveness Analysis of Surgical Treatment Modalities for Chondral Lesions of the Knee: Microfracture, Osteochondral Autograft Transplantation, and Autologous Chondrocyte Implantation.膝关节软骨损伤手术治疗方式的成本效益分析：微骨折术、自体骨软骨移植术和自体软骨细胞植入术
Orthop J Sports Med. 2017 May 3;5(5):2325967117704634. doi: 10.1177/2325967117704634. eCollection 2017 May.
2
Microfracture Versus Autologous Chondrocyte Implantation for Articular Cartilage Lesions in the Knee: A Systematic Review of 5-Year Outcomes.微骨折与自体软骨细胞移植治疗膝关节软骨病变的 5 年疗效的系统评价。
Am J Sports Med. 2018 Mar;46(4):995-999. doi: 10.1177/0363546517701912. Epub 2017 Apr 19.
3
Efficacy of mesenchymal stem cells in treating patients with osteoarthritis of the knee: A meta-analysis.间充质干细胞治疗膝骨关节炎患者的疗效：一项荟萃分析。
Exp Ther Med. 2016 Nov;12(5):3390-3400. doi: 10.3892/etm.2016.3791. Epub 2016 Oct 11.
4
Adipose Tissue and Mesenchymal Stem Cells: State of the Art and Lipogems® Technology Development.脂肪组织与间充质干细胞：现状与Lipogems®技术发展
Curr Stem Cell Rep. 2016;2(3):304-312. doi: 10.1007/s40778-016-0053-5. Epub 2016 Jul 13.
5
A Randomized Multicenter Trial Comparing Autologous Chondrocyte Implantation with Microfracture: Long-Term Follow-up at 14 to 15 Years.一项比较自体软骨细胞移植与微骨折术的随机多中心试验：14至15年的长期随访
J Bone Joint Surg Am. 2016 Aug 17;98(16):1332-9. doi: 10.2106/JBJS.15.01208.
6
The Long-Term Clinical Outcomes Following Autogenous Bone Grafting for Large-Volume Defects of the Knee: 12- to 21-Year Follow-Up.自体骨移植治疗膝关节大体积缺损的长期临床疗效：12 至 21 年随访结果。
Cartilage. 2014 Apr;5(2):86-96. doi: 10.1177/1947603513518216.
7
Clinical Outcomes following the Microfracture Procedure for Chondral Defects of the Knee: A Longitudinal Data Analysis.膝关节软骨缺损行微骨折术的临床疗效：纵向数据分析。
Cartilage. 2010 Apr;1(2):108-12. doi: 10.1177/1947603510366575.
8
Results at 10-14 years after microfracture treatment of articular cartilage defects in the knee.膝关节关节软骨缺损微骨折治疗10 - 14年后的结果
Knee Surg Sports Traumatol Arthrosc. 2016 May;24(5):1587-93. doi: 10.1007/s00167-014-3443-1. Epub 2014 Nov 23.
9
Clinical and radiological long-term outcomes after matrix-induced autologous chondrocyte transplantation: a prospective follow-up at a minimum of 10 years.基质诱导自体软骨细胞移植后的临床和放射学长期结果：至少10年的前瞻性随访
Am J Sports Med. 2014 Nov;42(11):2680-8. doi: 10.1177/0363546514548160. Epub 2014 Sep 9.
10
Long-term results of autologous chondrocyte implantation in the knee for chronic chondral and osteochondral defects.膝关节慢性软骨和骨软骨缺损自体软骨细胞植入的长期结果。
Am J Sports Med. 2014 Sep;42(9):2178-83. doi: 10.1177/0363546514539345. Epub 2014 Jul 7.
Zotero 插件