van Hage-Hamsten M, Ihre E, Zetterström O, Johansson S G
Dept. of Clinical Immunology, Karolinska Hospital, Stockholm, Sweden.
Allergy. 1988 Nov;43(8):545-51. doi: 10.1111/j.1398-9995.1988.tb00926.x.
Bronchial provocation studies with L. destructor (L. des.) extract were made on 12 farmers with asthma who were exposed daily to stored hay and grain and had positive radio-allergo-sorbent test (RAST) to L. des. All 12 farmers developed more than a 20% fall in FEV1 to the extract. None of the symptomatic farmers who were also RAST positive to the L. des. culture medium developed an asthmatic reaction to the medium extract. Neither four healthy farmers nor two patients with asthma caused by D. pteronyssinus (D. pt.) responded to L. des. or the L. des. culture medium. Challenges with D. pt. extract were negative in two symptomatic farmers who were RAST positive to L. des. and negative to D. pt. The present study further supports our previous hypothesis that there is an IgE-mediated immunological mechanism behind L. des.-induced asthma in farmers and that atopic farmers are liable to develop occupational asthma caused by allergy to L. des..
对12名患有哮喘的农民进行了用毁灭嗜皮菌（L. des.）提取物进行的支气管激发试验，这些农民每天接触储存的干草和谷物，且对L. des.的放射性变应原吸附试验（RAST）呈阳性。所有12名农民对该提取物的第一秒用力呼气量（FEV1）下降超过20%。对L. des.培养基RAST也呈阳性的有症状农民，均未对该培养基提取物产生哮喘反应。4名健康农民和2名由粉尘螨（D. pt.）引起哮喘的患者，均未对L. des.或L. des.培养基产生反应。对2名对L. des. RAST呈阳性而对D. pt.呈阴性的有症状农民进行粉尘螨提取物激发试验，结果为阴性。本研究进一步支持了我们之前的假设，即农民中由L. des.诱发的哮喘背后存在IgE介导的免疫机制，且特应性农民易患由对L. des.过敏引起的职业性哮喘。
