van Hage-Hamsten M, Johansson S G, Johansson E, Wiren A
Clin Allergy. 1987 Jan;17(1):23-31. doi: 10.1111/j.1365-2222.1987.tb02316.x.
The allergenic cross-reactivity between storage mites (Lepidoglyphus destructor, Glycyphagus domesticus, Tyrophagus putrescentiae and Acarus siro) and the house dust mite Dermatophagoides pteronyssinus was studied with the radio-allergo-sorbent test (RAST) and the RAST inhibition technique. RAST-positive sera were obtained from fifty-three farmers who were positive to at least one of the four storage mites. Sera from twelve of these farmers, eight of whom were also positive to D. pteronyssinus, were investigated with the RAST inhibition technique. No significant correlations were found between IgE-antibody levels to any single storage mite and D. pteronyssinus. There was no correlation between the RAST results to A. siro and G. domesticus, whereas a significant correlation was found between L. destructor, G. domesticus and T. putrescentiae. The RAST inhibition studies confirmed the greater allergenic similarity between L. destructor, G. domesticus and T. putrescentiae than between A. siro and the other three storage mites. The results of our studies support the hypothesis that each of the storage mites and D. pteronyssinus possess their own unique allergen or allergens. Furthermore, L. destructor, G. domesticus and T. putrescentiae seem to be allergenically more closely related to each other than to A. siro.
采用放射变应原吸附试验（RAST）和RAST抑制技术，研究了仓储螨（腐食酪螨、家甜食螨、嗜热放线菌螨和粉螨）与屋尘螨之间的变应原交叉反应性。从53名对四种仓储螨中至少一种呈阳性反应的农民中获得了RAST阳性血清。使用RAST抑制技术对其中12名农民的血清进行了研究，其中8名对屋尘螨也呈阳性反应。未发现针对任何一种单一仓储螨的IgE抗体水平与屋尘螨之间存在显著相关性。针对粉螨和家甜食螨的RAST结果之间没有相关性，而在腐食酪螨、家甜食螨和嗜热放线菌螨之间发现了显著相关性。RAST抑制研究证实，腐食酪螨、家甜食螨和嗜热放线菌螨之间的变应原相似性高于粉螨与其他三种仓储螨之间的变应原相似性。我们的研究结果支持以下假设：每种仓储螨和屋尘螨都有其自身独特的一种或多种变应原。此外，腐食酪螨、家甜食螨和嗜热放线菌螨在变应原方面似乎彼此之间的关系比与粉螨更为密切。
