Cui Xiaofang, Wei Wei, Qin Xiao, Hou Fei, Zhu Jin, Li Weiyang
Jining Medical University, Jining, Shandong, China.
Shandong Key Laboratory of Behavioral Medicine, School of Mental Health, Jining Medical University, Jining, Shandong, China.
PeerJ. 2020 Feb 7;8:e8545. doi: 10.7717/peerj.8545. eCollection 2020.
Stroke has become a major public health problem worldwide. In this article, we carried out statistical analysis, correlation analysis and principal component analysis (PCA) to evaluate the clinical value of routine hematological indicators in early diagnosis of ischemic stroke using R language.
For the full blood count comparisons, stroke patients had obvious differences in the distribution width of red blood cells (RDW-CV), average distribution width of red blood cells (RDW-SD), mean hemoglobin concentrations, platelet large cell ratio, mean platelet volume and lymphocytes. Patients with ischemic stroke also exhibited different degrees of abnormalities in liver function test. With respect to renal function, stroke patients had obvious changes in uric acid and urea levels. Finally, when comparing the lipid profile, triglyceride concentrations were increased and high-density lipoprotein cholesterol concentrations were reduced in stroke patients. In addition, correlation analysis among these clinical indicators indicated that there were both common characteristics and differences between patients and health controls. Furthermore, the results of PCA indicated that these clinical indicators could distinguish patients from the healthy controls.
Conventional hematological clinical indicators, such as liver function, renal function, full blood count and lipid concentration profiles highly correlated with the occurrence of ischemic stroke. Therefore, the detection and analyzation of these clinical indicators are of great significance for the prediction of ischemic stroke.
中风已成为全球主要的公共卫生问题。在本文中，我们使用R语言进行了统计分析、相关性分析和主成分分析（PCA），以评估常规血液学指标在缺血性中风早期诊断中的临床价值。
在全血细胞计数比较中，中风患者的红细胞分布宽度（RDW-CV）、红细胞平均分布宽度（RDW-SD）、平均血红蛋白浓度、血小板大细胞比率、平均血小板体积和淋巴细胞有明显差异。缺血性中风患者的肝功能检查也表现出不同程度的异常。在肾功能方面，中风患者的尿酸和尿素水平有明显变化。最后，在比较血脂谱时，中风患者的甘油三酯浓度升高，高密度脂蛋白胆固醇浓度降低。此外，这些临床指标之间的相关性分析表明，患者与健康对照者既有共同特征，也有差异。此外，主成分分析结果表明，这些临床指标可以区分患者与健康对照者。
常规血液学临床指标，如肝功能、肾功能、全血细胞计数和血脂浓度谱与缺血性中风的发生高度相关。因此，对这些临床指标的检测和分析对缺血性中风的预测具有重要意义。
