Emamian Marzieh, Hasanian Seyed Mahdi, Tayefi Maryam, Bijari Moniba, Movahedian Far Faeze, Shafiee Mojtaba, Avan Amir, Heidari-Bakavoli Alireza, Moohebati Mohsen, Ebrahimi Mahmoud, Darroudi Sousan, Zamani Parvin, Azarpazhooh Mahmoud Reza, Nematy Mohsen, Safarian Mohammad, Ferns Gordon A, Esmaeili Habibollah, Parizadeh Mohammad Reza, Ghayour-Mobarhan Majid
Metabolic Syndrome Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Department of Medical Biochemistry, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
J Clin Lab Anal. 2017 Nov;31(6). doi: 10.1002/jcla.22124. Epub 2017 Jan 20.
Hypertension (HTN) is a risk factor for stroke, renal failure, and cardiovascular disease. The association between biochemical and hematological parameters with high blood pressure may provide a more precise approach to risk prediction conferred by HTN in these patients.
The aim of current study was to explore whether biochemical and hematological parameters are associated with HTN in a cohort study with a 7-year follow-up.
A total of 9808 individuals were enrolled and recruited as part of the Mashhad Stroke and Heart Atherosclerotic Disorders (MASHAD) cohort study, and biochemical and hematological factors were measured in all subjects. Univariate and multivariate logistic regression analysis were performed to determine the association of biochemical and hematological parameters with HTN.
Several biochemical parameters including fasting plasma glucose (FBG), serum high-sensitivity C-reactive protein (hs-CRP), triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and uric acid were increased in hypertensive participants. In contrast, serum high-density lipoprotein cholesterol (HDL-C) was lower in hypertensive individuals. Furthermore, we demonstrated that hematological parameters including white blood cell (WBC) count, red blood cell (RBC) count, hemoglobin (HGB), hematocrit (HCT), and mean corpuscular hemoglobin (MCH) were higher in the hypertensive group compared to the control group. But mean corpuscular volume (MCV), and red cell distribution width (RDW), were decreased in the hypertensive group. Furthermore, our results strongly suggested that among these parameters, hematocrit was the independent risk factor for hypertension in the population.
We demonstrated the association of altered biochemical and hematological factors with hypertension supporting the value of emerging markers for early prediction of high blood pressure in prone individuals.
高血压（HTN）是中风、肾衰竭和心血管疾病的危险因素。生化和血液学参数与高血压之间的关联可能为这些患者中高血压所带来的风险预测提供更精确的方法。
本研究的目的是在一项为期7年随访的队列研究中探讨生化和血液学参数是否与高血压相关。
共有9808人作为马什哈德中风和心脏动脉粥样硬化疾病（MASHAD）队列研究的一部分被纳入并招募，所有受试者均测量了生化和血液学因素。进行单因素和多因素逻辑回归分析以确定生化和血液学参数与高血压的关联。
高血压参与者的几个生化参数升高，包括空腹血糖（FBG）、血清高敏C反应蛋白（hs-CRP）、甘油三酯（TG）、总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）和尿酸。相比之下，高血压个体的血清高密度脂蛋白胆固醇（HDL-C）较低。此外，我们证明高血压组的血液学参数包括白细胞（WBC）计数、红细胞（RBC）计数、血红蛋白（HGB）、血细胞比容（HCT）和平均红细胞血红蛋白（MCH）高于对照组。但高血压组的平均红细胞体积（MCV）和红细胞分布宽度（RDW）降低。此外，我们的结果强烈表明，在这些参数中，血细胞比容是该人群中高血压的独立危险因素。
我们证明了生化和血液学因素改变与高血压之间的关联，支持了新兴标志物对易患个体高血压早期预测的价值。
