Manda Chrispin Mahala, Hokimoto Takahiro, Okura Tomohiro, Isoda Hiroko, Shimano Hitoshi, Wagatsuma Yukiko
Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan.
Faculty of Health and Sport Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan.
Prev Med Rep. 2020 Jan 23;17:101056. doi: 10.1016/j.pmedr.2020.101056. eCollection 2020 Mar.
Conventional risk factors for prediabetes and type 2 diabetes such as obesity do not completely explain the higher prevalence of prediabetes; therefore, research to investigate the role of other independent risk factors is required. A few cross-sectional studies have reported an association between muscle strength and prediabetes among normal-weight adults, but the longitudinal relationship of muscle strength with incident prediabetes among adults has not been reported. This prospective cohort study was conducted to investigate whether relative handgrip strength in adults predicted prediabetes incidence after 2 years of follow-up. The study was conducted in Ibaraki prefecture, Japan and recruited individuals without prediabetes and diabetes attending lifestyle related medical examinations between April 2016 and March 2017 (n = 2054). Individuals who came for the follow-up medical examinations between April 2018 and March 2019 were included in the analysis (n = 1075). One hundred sixty-nine individuals (15.7%) developed prediabetes after a mean follow-up of 24.2 months (SD = 1.9 months). Multivariable adjusted hazard ratios (aHR) of new prediabetes cases were calculated using Cox regression. Higher baseline relative handgrip strength predicted a lower risk (aHR [95% CI] = 0.38 [0.21-0.71] of prediabetes incidence among adults. Importantly, relative handgrip strength predicted new prediabetes cases among normal weight individuals (aHR [95% CI] = 0.39 [0.16-0.96]). The findings suggest that handgrip strength measurement is useful to identify individuals at high risk of newly diagnosed prediabetes, importantly, among normal weight individuals. The identified individuals may benefit from early intervention to reduce the risk of prediabetes.
诸如肥胖等糖尿病前期和2型糖尿病的传统风险因素并不能完全解释糖尿病前期较高的患病率；因此，需要开展研究来调查其他独立风险因素的作用。一些横断面研究报告了正常体重成年人的肌肉力量与糖尿病前期之间的关联，但尚未有关于成年人肌肉力量与新发糖尿病前期之间纵向关系的报道。本前瞻性队列研究旨在调查成年人的相对握力是否能预测2年随访后的糖尿病前期发病率。该研究在日本茨城县进行，招募了2016年4月至2017年3月期间参加与生活方式相关体检且无糖尿病前期和糖尿病的个体（n = 2054）。2018年4月至2019年3月前来进行随访体检的个体被纳入分析（n = 1075）。在平均24.2个月（标准差 = 1.9个月）的随访后，169名个体（15.7%）发展为糖尿病前期。使用Cox回归计算新糖尿病前期病例的多变量调整风险比（aHR）。较高的基线相对握力预示成年人患糖尿病前期的风险较低（aHR [95%置信区间] = 0.38 [0.21 - 0.71]）。重要的是，相对握力可预测正常体重个体中的新发糖尿病前期病例（aHR [95%置信区间] = 0.39 [0.16 - 0.96]）。研究结果表明，测量握力有助于识别新诊断为糖尿病前期的高危个体，重要的是在正常体重个体中。识别出的个体可能受益于早期干预以降低糖尿病前期风险。
