观察性研究：握力、身体成分与糖尿病。
Observational study: handgrip strength, body composition and diabetes mellitus.
机构信息
School of Medicine and Medical Science, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8575, Japan.
Department of Clinical Trials and Clinical Epidemiology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8575, Japan.
出版信息
BMC Res Notes. 2021 Aug 28;14(1):332. doi: 10.1186/s13104-021-05731-4.
OBJECTIVE
Previous studies have shown that relative handgrip strength, handgrip measure divided by body mass index (BMI), affects the future onset of diabetes and prediabetes. However, fat free mass (FFM) has been suggested to adjust for this effect better than BMI. In this study, we examined applicability of models that adjusted handgrip-diabetes relationship with either BMI or FFM.
RESULTS
Of 1940 participants (56.2% male, average (SD) age, 57.2 [11.2] years), 267 (13.8%) had diabetes (DM) and 912 (47.0%) had prediabetes (pre-DM). The average handgrip measure for men was 40.0 kg (tertile measures, 37.4 kg and 42.5 kg) and for women 24.2 kg (tertile measures, 22.6 kg and 25.7 kg). Among both sexes, the percentage of people unaffected by DM or pre-DM was highest in the strong handgrip group and lowest in the weak handgrip group. Analysis using binary logistic models showed that an increase in handgrip measure was associated with a decrease in the chance of having either pre-DM or DM. This effect was detected by both BMI models and FFM models, even after adjustment for medical and lifestyle factors. Either or both should be used depending on the research aims, setting and methods.
目的
先前的研究表明，相对握力，即握力除以体重指数（BMI），会影响糖尿病和糖尿病前期的发病。然而，与 BMI 相比，瘦体重（FFM）更能调整这种影响。本研究旨在检验用 BMI 或 FFM 调整握力与糖尿病关系的模型的适用性。
结果
在 1940 名参与者中（56.2%为男性，平均（SD）年龄为 57.2[11.2]岁），267 名（13.8%）患有糖尿病（DM），912 名（47.0%）患有糖尿病前期（pre-DM）。男性的平均握力测量值为 40.0kg（三分位值分别为 37.4kg 和 42.5kg），女性为 24.2kg（三分位值分别为 22.6kg 和 25.7kg）。在男女两性中，不受 DM 或 pre-DM 影响的人群在握力强的组中比例最高，在握力弱的组中比例最低。使用二元逻辑模型进行分析表明，握力测量值的增加与 pre-DM 或 DM 发生几率的降低有关。即使在调整了医疗和生活方式因素后，BMI 模型和 FFM 模型都能检测到这种影响。应根据研究目的、背景和方法，选择使用其中一种或两种模型。
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