在韩国人群中，相对较低的手部握力与糖尿病风险增加和空腹血糖受损相关。
Low relative hand grip strength is associated with a higher risk for diabetes and impaired fasting glucose among the Korean population.
机构信息
Division of Endocrinology and Metabolism, Department of Internal Medicine, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Yangsan, Korea.
Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Korea.
出版信息
PLoS One. 2022 Oct 6;17(10):e0275746. doi: 10.1371/journal.pone.0275746. eCollection 2022.
OBJECTIVE
This study investigated the association between relative hand grip strength (HGS) and glycemic status, such as impaired fasting glucose (IFG) and diabetes, using data from the Korea National Health and Nutrition Examination Survey (KNHANES).
METHODS
We performed a cross-sectional study using the data from the KNHANES of 27,894 individuals from 2014 to 2019. Relative HGS was defined as the absolute HGS divided by body mass index and divided into quartiles in men and women. Odds ratios (OR) for diabetes and IFG were calculated using multivariate logistic regression analysis. All analyses were stratified by sex, and subgroup analysis was age-stratified.
RESULTS
The lowest relative HGS quartile had a significant increase in the risk for diabetes (men: OR 2.72, 95% confidence interval [CI] 2.12-3.50; women: OR 3.38, 95% CI 2.70-4.24) and IFG (men: OR 1.35, 95% CI 1.15-1.59; women: OR 1.60, 95% CI 1.40-1.84). The ORs for diabetes and IFG according to the decreasing quartiles of relative HGS gradually increased in both sexes (P for trend <0.001). ORs and 95% CI of the lowest relative HGS quartile for diabetes were higher in the younger age group than that of the older age group (men: 4.47 and 2.80-7.14 for young adults; 2.41 and 1.37-4.25 for older adults; women: 5.91 and 3.06-9.38 for young adults; 1.47 and 0.92-2.33 for older adults). ORs and 95% CI for IFG was similar with the trend of ORs for diabetes (men: 1.80 and 1.43-2.26 for young adults; 1.17 and 0.75-1.84 for older adults; women: 2.20 and 1.77-2.72 for young adults; 1.33 and 0.86-2.07 for older adults).
CONCLUSION
Lower relative HGS was associated with a higher risk of not only diabetes but also IFG in both sexes. These trends were stronger in younger adults than in older adults.
目的
本研究使用 2014 年至 2019 年韩国国民健康与营养调查（KNHANES）的数据，探讨相对握力（HGS）与血糖状态（如空腹血糖受损[IFG]和糖尿病）之间的关系。
方法
我们进行了一项横断面研究，使用了来自 27894 名男性和女性的 KNHANES 数据。相对 HGS 定义为绝对 HGS 除以体重指数，并按性别分为四分位。使用多变量逻辑回归分析计算糖尿病和 IFG 的比值比（OR）。所有分析均按性别分层，亚组分析按年龄分层。
结果
最低相对 HGS 四分位数的糖尿病风险显著增加（男性：OR 2.72，95%置信区间[CI] 2.12-3.50；女性：OR 3.38，95%CI 2.70-4.24）和 IFG（男性：OR 1.35，95%CI 1.15-1.59；女性：OR 1.60，95%CI 1.40-1.84）。在两性中，相对 HGS 四分位数降低与糖尿病和 IFG 的 OR 逐渐增加（趋势 P<0.001）。在年龄较小的年龄组中，最低相对 HGS 四分位数的糖尿病 OR 高于年龄较大的年龄组（男性：年轻人 4.47 和 2.80-7.14；老年人 2.41 和 1.37-4.25；女性：年轻人 5.91 和 3.06-9.38；老年人 1.47 和 0.92-2.33）。IFG 的 OR 和 95%CI 与糖尿病 OR 的趋势相似（男性：年轻人 1.80 和 1.43-2.26；老年人 1.17 和 0.75-1.84；女性：年轻人 2.20 和 1.77-2.72；老年人 1.33 和 0.86-2.07）。
结论
相对 HGS 较低与两性中糖尿病和 IFG 的风险增加有关。这些趋势在年轻人中比在老年人中更强。
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