Puri Basant K, Heard Christopher R, Monro Jean A
C.A.R., Cambridge, UK.
Imaging Directorate, Hammersmith Hospital, London, UK.
J Oral Biol Craniofac Res. 2020 Apr-Jun;10(2):20-22. doi: 10.1016/j.jobcr.2020.01.010. Epub 2020 Feb 6.
The salivary caffeine clearance is a non-invasive, safe, saliva-based method for assessing hepatic function and diagnosing chronic liver disease. The elimination of caffeine from the body follows first-order kinetics and principally involves catabolism by hepatic CYP1A2, with a half-life usually between three and 7 h. It is known that this process is affected by age and smoking tobacco. It has been suggested that sex might also be important, but there is scant evidence for this. The aim of this study was to assess whether there is a sex difference in salivary caffeine clearance in adults.
A cohort of 213 adults was studied. They were all non-smokers and none suffered from chronic liver disease. They consisted of 67 men (mean age 40.0 years) and 146 women (mean age 44.7 years). Following a period of dietary caffeine abstinence lasting at least 24 h, each subject ingested a single oral dose in the morning of caffeine, at a dose of 3 mg per kg body mass. Salivary samples were collected at 2 h and 14 h post-caffeine ingestion and were spectrophotometrically assayed for their caffeine concentrations.
The two groups were matched for age. The mean (standard error) salivary caffeine clearance in the male subjects was 1.51 (0.10) mL min kg, while that in the female subjects was 1.60 (0.07) mL min kg ( = 0.495).
This relatively large study provides no evidence of a sex difference in salivary caffeine clearance.
唾液咖啡因清除率是一种用于评估肝功能和诊断慢性肝病的非侵入性、安全的基于唾液的方法。咖啡因从体内的消除遵循一级动力学，主要通过肝脏细胞色素P450 1A2（CYP1A2）进行分解代谢，半衰期通常在3至7小时之间。已知这个过程会受到年龄和吸烟的影响。有人提出性别可能也很重要，但对此几乎没有证据。本研究的目的是评估成年人唾液咖啡因清除率是否存在性别差异。
对213名成年人进行了队列研究。他们均为非吸烟者，且无慢性肝病患者。其中包括67名男性（平均年龄40.0岁）和146名女性（平均年龄44.7岁）。在至少24小时的饮食中 abstinence咖啡因后，每位受试者在早晨口服单剂量咖啡因，剂量为每千克体重3毫克。在摄入咖啡因后2小时和14小时收集唾液样本，并通过分光光度法测定其咖啡因浓度。
两组年龄匹配。男性受试者的平均（标准误差）唾液咖啡因清除率为1.51（0.10）毫升/分钟/千克，而女性受试者为1.60（0.07）毫升/分钟/千克（P = 0.495）。
这项规模相对较大的研究没有提供唾液咖啡因清除率存在性别差异的证据。
