Baizabal-Carvallo José Fidel, Jankovic Joseph
Parkinson's Disease Center and Movement Disorders Clinic, Department of Neurology Baylor College of Medicine Houston Texas USA.
Department of Internal Medicine University of Guanajuato Leon México.
Mov Disord Clin Pract. 2019 Dec 24;7(2):182-187. doi: 10.1002/mdc3.12864. eCollection 2020 Feb.
Functional neurological disorders are generally more common in females than males, but the reason for this gender difference is not well understood.
In this study, we aim to compare the clinical and demographic features of functional movement disorders (FMDs) between males and females.
We examined clinical data and video-recordings of patients with FMDs evaluated at the Baylor College of Medicine Movement Disorders Clinic.
Of the 196 patients with FMDs, males represented only 30% (n = 59) of the entire cohort. Men had an older age at onset: 40.5 versus 34.1 years ( = 0.026) and an older age at evaluation: 43.8 versus 38.1 years ( = 0.041) compared to women. Functional dystonia was more frequently observed in women: 47.5 versus 20.3% ( < 0.001), but there was a trend for higher frequency of functional gait disorder in men: 44 versus 30% ( = 0.056). Females were particularly over-represented (73.7%) in children and adolescents; but the genders were equally represented in patients aged ≥50 years.
Female patients are over-represented in FMDs, except in individuals aged ≥50 years. Compared to female patients, males with FMDs present later in life and are less likely to have functional dystonia.
功能性神经障碍在女性中通常比男性更常见，但这种性别差异的原因尚不清楚。
在本研究中，我们旨在比较男性和女性功能性运动障碍（FMD）的临床和人口统计学特征。
我们检查了在贝勒医学院运动障碍诊所接受评估的FMD患者的临床数据和视频记录。
在196例FMD患者中，男性仅占整个队列的30%（n = 59）。与女性相比，男性发病年龄较大：40.5岁对34.1岁（P = 0.026），评估时年龄也较大：43.8岁对38.1岁（P = 0.041）。女性中功能性肌张力障碍更为常见：47.5%对20.3%（P < 0.001），但男性功能性步态障碍的发生率有更高的趋势：44%对30%（P = 0.056）。女性在儿童和青少年中占比尤其过高（73.7%）；但在年龄≥50岁的患者中，男女比例相当。
除年龄≥50岁的个体外，FMD患者中女性占比过高。与女性患者相比，患有FMD的男性发病较晚，且患功能性肌张力障碍的可能性较小。
