Sasaki Takashi, Niizuma Kuniyasu, Kanoke Atsushi, Matsui Keiko, Ogita Shogo, Rashad Sherif, Kawai Tadashi, Watanabe Mika, Endo Hidenori, Takahashi Tetsu, Kamakura Shinji, Tominaga Teiji
Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Japan.
Department of Neurosurgical Engineering and Translational Neuroscience, Graduate School of Biomedical Engineering, Tohoku University, Sendai, Japan.
Heliyon. 2020 Feb 6;6(2):e03347. doi: 10.1016/j.heliyon.2020.e03347. eCollection 2020 Feb.
Cranial bone defects are a major issue in the field of neurosurgery, and improper management of such defects can cause cosmetic issues as well as more serious infections and inflammation. Several strategies exist to manage these defects clinically, but most rely on synthetic materials that are prone to complications; thus, a bone regenerative approach would be superior. We tested a material (octacalcium phosphate collagen composite [OCP/Col]) that is known to enhance bone regeneration in a skull defect model in rats. Using a critical-sized rat skull defect model, OCP/Col was implanted in rats with an intact dura or with a partial defect of the dura. The results were compared with those in a no-treatment group over the course of 12 weeks using computed tomographic and histological analysis. OCP/Col enhanced bone regeneration, regardless of whether there was a defect of the dura. OCP/Col can be used to treat skull defects, even when the dura is injured or removed surgically, via bone regeneration with enhanced resorption of OCP/Col, thus limiting the risk of infection greatly.
颅骨缺损是神经外科领域的一个主要问题，对此类缺损处理不当会导致美容问题以及更严重的感染和炎症。临床上有多种处理这些缺损的策略，但大多数依赖于容易引发并发症的合成材料；因此，骨再生方法会更具优势。我们在大鼠颅骨缺损模型中测试了一种已知能促进骨再生的材料（磷酸八钙胶原蛋白复合物[OCP/Col]）。使用临界大小的大鼠颅骨缺损模型，将OCP/Col植入硬脑膜完整或硬脑膜部分缺损的大鼠体内。在12周的时间里，通过计算机断层扫描和组织学分析，将结果与未治疗组进行比较。无论硬脑膜是否有缺损，OCP/Col均可促进骨再生。OCP/Col可用于治疗颅骨缺损，即使硬脑膜受到损伤或手术切除，通过增强OCP/Col的吸收实现骨再生，从而大大降低感染风险。
