Department of Trauma Surgery, University Hospital of the RWTH Aachen, Aachen, Germany.
Injury. 2011 Jun;42(6):569-73. doi: 10.1016/j.injury.2011.03.033. Epub 2011 Apr 12.
Critical sized bone defects have to be filled with material to allow bone healing. The golden standard for this treatment is autogenous bone grafting. Because of donor size morbidity, equivalent synthetic bone scaffolds should be developed. Different materials, especially ceramics and polymers are in the focus of research. Calcium phosphate ceramics show similar properties to bone and are degradable. Different modifications can improve the bioactive features. This article gives an overview about the current materials and their evidence of clinical use.
临界尺寸的骨缺损必须用材料填充才能允许骨愈合。这种治疗的金标准是自体骨移植。由于供体尺寸的发病率，应开发等效的合成骨支架。不同的材料，特别是陶瓷和聚合物，是研究的重点。磷酸钙陶瓷具有与骨骼相似的特性，并且可降解。不同的改性可以改善生物活性特征。本文概述了目前的材料及其临床应用证据。
