Jiang Yan, Clarke John O
Division of Gastroenterology and Hepatology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA.
, Redwood City, USA.
Curr Treat Options Gastroenterol. 2020 Feb 19;18(1):69-81. doi: 10.1007/s11938-020-00275-1. Print 2020 Mar.
To examine recent key developments in the pathophysiology, diagnosis, and treatment of gastroesophageal reflux disease (GERD).
Newer research has suggested cytokine-mediated inflammation may play a role in the physiology of GERD, implying that the underlying mechanism may not be entirely related to chemical damage due to acid. Aided by novel technologies, diagnostic testing is also moving toward elucidating individual mechanisms and better defining specific GERD phenotypes with the goal of providing directed therapy. This is especially important in current times given the increase in coverage of adverse events reportedly linked to long-term proton pump inhibitor use.
As patients are looking for potential alternatives, we highlight the key recent updates in pathophysiology and understanding of GERD and current medical and endoscopic/surgical options and explore the exciting treatments in the pipeline.
探讨胃食管反流病（GERD）病理生理学、诊断及治疗方面的近期关键进展。
最新研究表明，细胞因子介导的炎症可能在GERD生理过程中发挥作用，这意味着潜在机制可能并非完全与酸引起的化学损伤相关。在新技术的辅助下，诊断测试也朝着阐明个体机制以及更好地定义特定GERD表型的方向发展，目标是提供针对性治疗。鉴于据报道与长期使用质子泵抑制剂相关的不良事件发生率增加，这一点在当前尤为重要。
由于患者在寻求潜在替代方案，我们重点介绍GERD病理生理学和认识方面的近期关键更新、当前的药物及内镜/手术选择，并探索正在研发的令人兴奋的治疗方法。
