Department of Biology, Clarkson University, Potsdam, NY, USA.
National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Adv Exp Med Biol. 2020;1227:51-68. doi: 10.1007/978-3-030-36422-9_4.
The Notch signaling pathway seems deceptively simple, with its key feature being a direct connection between extracellular signal and transcriptional output without the need for an extended chain of protein intermediaries as required by so many other signaling paradigms. However, this apparent simplicity hides considerable complexity. Consistent with its central role in many aspects of development, Notch signaling has an extensive collection of mechanisms that it employs alongside of its core transcriptional machinery. These so-called noncanonical Notch pathways diversify the potential outputs of Notch, and allow it to coordinate regulation of many aspects of the biology of cells. Here we will review noncanonical Notch signaling with special attention to the role of posttranslational modifications of Notch. We will also consider the importance of coordinating the activity of gene expression with regulation of cell morphology in biological processes, including axon guidance and other morphological events during embryogenesis.
Notch 信号通路看似简单，其主要特点是细胞外信号与转录输出之间的直接连接，而不需要像许多其他信号模式那样需要一系列延伸的蛋白中介。然而，这种表面上的简单性隐藏着相当大的复杂性。Notch 信号在发育的许多方面发挥着核心作用，它与核心转录机制一起使用了大量的机制。这些所谓的非经典 Notch 途径使 Notch 的潜在输出多样化，并使其能够协调细胞生物学的许多方面的调控。在这里，我们将特别关注 Notch 的翻译后修饰在非经典 Notch 信号中的作用，来回顾非经典 Notch 信号。我们还将考虑协调基因表达活性与细胞形态调节在包括轴突导向和胚胎发生期间其他形态事件等生物过程中的重要性。
