Department of Cell and Molecular Biology, Karolinska Institute, SE-171 77 Stockholm, Sweden.
Development. 2011 Sep;138(17):3593-612. doi: 10.1242/dev.063610.
Notch signaling is evolutionarily conserved and operates in many cell types and at various stages during development. Notch signaling must therefore be able to generate appropriate signaling outputs in a variety of cellular contexts. This need for versatility in Notch signaling is in apparent contrast to the simple molecular design of the core pathway. Here, we review recent studies in nematodes, Drosophila and vertebrate systems that begin to shed light on how versatility in Notch signaling output is generated, how signal strength is modulated, and how cross-talk between the Notch pathway and other intracellular signaling systems, such as the Wnt, hypoxia and BMP pathways, contributes to signaling diversity.
Notch 信号转导在进化上是保守的，在发育的许多细胞类型和不同阶段发挥作用。因此，Notch 信号转导必须能够在各种细胞环境中产生适当的信号转导输出。Notch 信号转导的这种多功能性需求与核心途径的简单分子设计明显形成对比。在这里，我们回顾了线虫、果蝇和脊椎动物系统中的最新研究，这些研究开始阐明 Notch 信号转导输出的多功能性是如何产生的，信号强度是如何调节的，以及 Notch 途径与其他细胞内信号转导系统（如 Wnt、缺氧和 BMP 途径）之间的串扰如何促进信号多样性。
