磺酰胺的顺序碳-硫和硫-氮偶联方法。
Sequential C-S and S-N Coupling Approach to Sulfonamides.
作者信息
Chen Kai, Chen Wei, Han Bing, Chen Wanzhi, Liu Miaochang, Wu Huayue
机构信息
Department of Chemistry, Zhejiang University, 38 Zheda Road, Hangzhou 310027, China.
College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325027, China.
出版信息
Org Lett. 2020 Mar 6;22(5):1841-1845. doi: 10.1021/acs.orglett.0c00183. Epub 2020 Feb 19.
A one-pot three-component reaction involving nitroarenes, (hetero)arylboronic acids, and potassium pyrosulfite leading to sulfonamides was described. A broad range of sulfonamides bearing different reactive functional groups were obtained in good to excellent yields through sequential C-S and S-N coupling that does not require metal catalysts.
描述了一种涉及硝基芳烃、（杂）芳基硼酸和焦亚硫酸钾生成磺酰胺的一锅三组分反应。通过无需金属催化剂的顺序C-S和S-N偶联，以良好至优异的产率获得了一系列带有不同反应性官能团的磺酰胺。
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