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法国肝脏分配系统的发展与成果。

Development and outcomes of the French liver allocation system.

作者信息

Durand François

机构信息

Hepatology and Liver Intensive Care, Hospital Beaujon, University of Paris, INSERM U1149, Clichy, France.

出版信息

Curr Opin Organ Transplant. 2020 Apr;25(2):132-138. doi: 10.1097/MOT.0000000000000749.

Abstract

PURPOSE OF REVIEW

Although most countries adopted the Model for End Stage Liver Disease (MELD) score for prioritization in liver transplantation, differences exist from country to country. The purpose of the review is to present the specificity of the French allocation policy.

RECENT FINDINGS

Organ allocation in France is typically based on the MELD score and the distance between the donor and the recipient at a national level. Organs are offered to patients on a national basis, not to centers. Patients with hepatocellular carcinoma and α-fetoprotein score 2 or less receive extra points to have access to transplantation similar to that of patients with cirrhosis. A third category is represented by MELD exceptions where MELD score is inaccurate at predicting outcome. MELD exceptions include complications of cirrhosis such as refractory ascites and other conditions such as polycystic liver disease. The objective is to guarantee similar waiting list mortality and similar posttransplant outcomes for each of these categories.

SUMMARY

The French allocation system has been created with MELD as reference for prioritization, but it also takes into account distance between the donor and the recipient. Patients with hepatocellular carcinoma and patients with MELD exceptions are prioritized to have a similar access to transplantation.

摘要

综述目的

尽管大多数国家采用终末期肝病模型(MELD)评分来确定肝移植的优先顺序,但各国之间存在差异。本综述的目的是介绍法国分配政策的特殊性。

最新研究结果

法国的器官分配通常基于MELD评分以及全国范围内供体与受体之间的距离。器官是在全国范围内提供给患者,而非各个中心。肝细胞癌且甲胎蛋白评分小于或等于2的患者可获得额外加分,从而获得与肝硬化患者相似的移植机会。第三类情况是MELD例外,即MELD评分在预测预后方面不准确。MELD例外包括肝硬化并发症,如难治性腹水,以及其他病症,如多囊肝病。目的是确保这些类别中的每一类在等待名单上的死亡率相似,移植后结果也相似。

总结

法国的分配系统以MELD作为优先排序的参考标准,但同时也考虑了供体与受体之间的距离。肝细胞癌患者和MELD例外患者在获得移植机会方面享有优先权。

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