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多年来肝脏分配的基本原则及发展情况。

Basic principles of liver allocation and development over the years.

作者信息

Aby Elizabeth S, Lake John R

机构信息

Division of Gastroenterology, Hepatology, and Nutrition, University of Minnesota, Minneapolis, Minnesota, USA.

出版信息

Curr Opin Organ Transplant. 2020 Apr;25(2):99-103. doi: 10.1097/MOT.0000000000000732.

Abstract

PURPOSE OF REVIEW

Prior to the enactment of the National Organ Transplant Act in 1984, there was no organized system to allocate donor organs in the United States. The process of liver allocation has come a long way since then, including the development and implementation of the Model for End-stage Liver Disease, which is an objective estimate of risk of mortality among candidates awaiting liver transplantation.

RECENT FINDINGS

The Liver Transplant Community is constantly working to optimize the distribution and allocation of scare organs, which is essential to promote equitable access to a life-saving procedure in the setting of clinical advances in the treatment of liver disease. Over the past 17 years, many changes have been made. Most recently, liver distribution changed such that deceased donor livers will be distributed based on units established by geographic circles around a donor hospital rather than the current policy, which uses donor service areas as the unit of distribution. In addition, a National Liver Review Board was created to standardize the process of determining liver transplant priority for candidates with exceptional medical conditions. The aim of these changes is to allocate and distribute organs in an efficient and equitable fashion.

SUMMARY

The current review provides a historical perspective of liver allocation and the changing landscape in the United States.

摘要

综述目的

在1984年《国家器官移植法》颁布之前,美国没有一个有组织的系统来分配捐赠器官。从那时起,肝脏分配过程已经取得了长足的进步,包括终末期肝病模型的开发和实施,这是对等待肝移植的候选人死亡风险的客观评估。

最新发现

肝脏移植界一直在努力优化稀缺器官的分配,这对于在肝病治疗临床进展的背景下促进公平获得挽救生命的手术至关重要。在过去的17年里,发生了许多变化。最近,肝脏分配发生了变化,即已故捐赠者的肝脏将根据捐赠医院周围地理区域划分的单位进行分配,而不是目前以捐赠服务区域作为分配单位的政策。此外,还设立了一个国家肝脏审查委员会,以规范为患有特殊医疗状况的候选人确定肝移植优先级的过程。这些变化的目的是以高效和公平的方式分配器官。

总结

本综述提供了美国肝脏分配的历史视角以及不断变化的情况。

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