Department of Ophthalmology, Centre Hospitalier Intercommunal de Créteil, Créteil, France; and.
Unit Signal, Image and Optimization(SIMO), Laboratory of Images, Signals and Intelligent Systems (LISSI), (EA N ° 3956), University Paris-Est Créteil, Créteil, France.
Retina. 2020 Dec;40(12):2325-2331. doi: 10.1097/IAE.0000000000002777.
To evaluate vascular density (VD), fractal dimension, and skeletal density on optical coherence tomography angiography in eyes with idiopathic foveal hypoplasia (IFH).
Patients presenting with IFH to Creteil University Eye Clinic between January 2015 and October 2018 and age-matched healthy controls were retrospectively evaluated. Vascular density, skeletal density, and fractal dimension analyses were computed on optical coherence tomography angiography superficial capillary plexa (SCP) and deep capillary plexa (DCP) images on the whole image using a custom algorithm. Vascular density on the central 1 mm and the peripheral 8 mm for the two groups was performed.
Thirty-six eyes of 21 patients (18 eyes with IFH and 18 control eyes) were included. A decrease of VD at the level of the SCP and DCP was found in eyes with IFH compared with healthy control eyes (P = 0.005 for VD at the level of the SCP and P = 0.003 for VD at the level of the DCP, respectively). On the central 1 mm, VD was decreased in healthy eyes (32.3% ± 4.8) at the level of the SCP compared to IFH eyes (55.6% ± 46.3) (P < 0.001). Skeletal density was decreased in IFH eyes in both SCP and DCP (P =< 0.001). Fractal dimension was lower in IFH eyes in both SCP and DCP (P < 0.001).
Vascular density, skeletal density, and fractal dimension are reduced at the level of SCP and DCP in patients with IFH compared with controls, reflecting a particular anatomical and vascular organization. Quantitative analysis using optical coherence tomography angiography could help to evaluate the severity of IFH.
评估特发性黄斑部神经纤维层缺损（IFH）患者的光学相干断层扫描血管造影（OCTA）中的血管密度（VD）、分形维数和骨密度。
回顾性分析 2015 年 1 月至 2018 年 10 月在克雷泰伊大学眼科诊所就诊的 IFH 患者和年龄匹配的健康对照组。使用定制算法在 OCTA 浅层毛细血管丛（SCP）和深层毛细血管丛（DCP）图像上对整个图像进行血管密度、骨密度和分形维数分析。对两组中央 1mm 和周围 8mm 的血管密度进行了评估。
共纳入 21 例患者（18 例 IFH 眼和 18 例对照眼）的 36 只眼。与健康对照组相比，IFH 眼中的 SCP 和 DCP 水平的 VD 降低（SCP 水平的 VD 分别为 P=0.005 和 DCP 水平的 P=0.003）。在中央 1mm 处，健康眼的 SCP 层 VD（32.3%±4.8）较 IFH 眼（55.6%±46.3）降低（P<0.001）。SCP 和 DCP 中 IFH 眼的骨密度均降低（P<0.001）。SCP 和 DCP 中 IFH 眼的分形维数均较低（P<0.001）。
与对照组相比，IFH 患者的 SCP 和 DCP 水平的 VD、骨密度和分形维数降低，反映了特定的解剖和血管组织。OCTA 定量分析有助于评估 IFH 的严重程度。
