弱视儿童与健康对照儿童眼黄斑无血管区定量测量及黄斑血管密度比较：光学相干断层扫描血管造影研究
Comparison of quantitative measurement of foveal avascular zone and macular vessel density in eyes of children with amblyopia and healthy controls: an optical coherence tomography angiography study.
作者信息
Yilmaz Ihsan, Ocak Osman Bulut, Yilmaz Basak Saracoglu, Inal Aslı, Gokyigit Birsen, Taskapili Muhittin
机构信息
Department of Ophthalmology, University of Health Sciences, Beyoglu Eye Training and Research Hospital, Istanbul.
Department of Ophthalmology, University of Health Sciences, Beyoglu Eye Training and Research Hospital, Istanbul.
出版信息
J AAPOS. 2017 Jun;21(3):224-228. doi: 10.1016/j.jaapos.2017.05.002. Epub 2017 May 10.
PURPOSE
To quantify vessel density of superficial capillary plexus (SCP), deep capillary plexus (DCP), and the foveal avascular zone (FAZ) of children's amblyopic eyes and to compare the measurements with those of companion eyes and age-matched controls.
METHODS
Fifteen patients with strabismic amblyopia, and 15 age-matched controls were included in this cross-sectional study. SCP, DCP, and FAZ were measured via optical coherence tomographic angiography (OCTA).
RESULTS
Mean subject age was 8.2 ± 2.3 years in the amblyopia group and 8.6 ± 2.2 years in the control group. The mean SCP at 1 mm, 2 mm, and 3 mm zones were (in the order amblyopic eye, companion eye, control) 1.399 ± 0.088, 5.854 ± 0.195, 12.866 ± 0.346; 1.467 ± 0.084, 5.979 ± 0.182, 12.965 ± 0.321; and 1.559 ± 0.052, 6.343 ± 0.190, 13.819 ± 0.423. SCP was significantly lower in amblyopic eyes than in companion eyes and controls (P < 0.05). The mean DCP at 1 mm, 2 mm, and 3 mm zones were 1.425 ± 0.069, 6.038 ± 0.186, 13.522 ± 0.336; 1.525 ± 0.072, 6.427 ± 0.190, 14.286 ± 0.322; and 1.685 ± 0.074, 6.895 ± 0.198, 15.355 ± 0.356. DCP was significantly lower in amblyopic eyes than companion eyes and controls (P < 0.05). The mean superficial FAZ were 0.287 ± 0.091, 0.262 ± 0.092, and 0.280 ± 0.097. The mean deep FAZ were 0.382 ± 0.092, 0.335 ± 0.080, and 0.329 ± 0.085. There was no significant difference in FAZ among groups (P > 0.05).
CONCLUSIONS
Vessel density of SCP and DCP of eyes with amblyopia is lower than that of the companion eye and the age-matched controls.
目的
量化儿童弱视眼的浅表毛细血管丛（SCP）、深部毛细血管丛（DCP）及黄斑无血管区（FAZ）的血管密度，并将测量结果与对侧眼及年龄匹配的对照组进行比较。
方法
本横断面研究纳入了15例斜视性弱视患者及15例年龄匹配的对照者。通过光学相干断层扫描血管造影（OCTA）测量SCP、DCP及FAZ。
结果
弱视组的平均受试者年龄为8.2±2.3岁，对照组为8.6±2.2岁。在1mm、2mm和3mm区域，SCP的平均值（顺序为弱视眼、对侧眼、对照组）分别为1.399±0.088、5.854±0.195和12.866±0.346；1.467±0.084、5.979±0.182和12.965±0.321；以及1.559±0.052、6.343±0.190和13.819±0.423。弱视眼的SCP显著低于对侧眼和对照组（P<0.05）。在1mm、2mm和3mm区域，DCP的平均值分别为1.425±0.069、6.038±0.186和13.522±0.336；1.525±0.072、6.427±0.190和14.286±0.322；以及1.685±0.074、6.895±0.198和15.355±0.356。弱视眼的DCP显著低于对侧眼和对照组（P<0.05）。浅表FAZ的平均值分别为0.287±0.091、0.262±0.092和0.280±0.097。深部FAZ的平均值分别为0.382±0.092、0.335±0.080和0.329±0.085。各组间FAZ无显著差异（P>0.05）。
结论
弱视眼SCP和DCP的血管密度低于对侧眼及年龄匹配的对照组。
Zotero 插件